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Titolo:
Local cerebral glucose utilization rates in alcohol-naive high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats
Autore:
Learn, JE; Smith, DG; McBride, WJ; Lumeng, L; Li, TK;
Indirizzi:
Indiana Univ, Sch Med, Inst Psychiat Res, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 at Res, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Program Med Neurobiol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 robiol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Program Psychol Addict, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 Addict, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 pt Med, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Biochem, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 iochem, Indianapolis, IN 46202 USA VAMC, Indianapolis, IN 46202 USA VAMC Indianapolis IN USA 46202VAMC, Indianapolis, IN 46202 USA
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 4, volume: 25, anno: 2001,
pagine: 517 - 523
SICI:
0145-6008(200104)25:4<517:LCGURI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOLISM; ETHANOL; CONSEQUENCES; SEROTONIN; DOPAMINE; RODENTS;
Keywords:
2-deoxyglucose; high-alcohol-drinking rats; functional imaging; local cerebral glucose utilization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: McBride, WJ Indiana Univ, Sch Med, Inst Psychiat Res, 791 Union Dr, Indianapolis, IN 46202 USA Indiana Univ 791 Union Dr Indianapolis IN USA 46202 46202 USA
Citazione:
J.E. Learn et al., "Local cerebral glucose utilization rates in alcohol-naive high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats", ALC CLIN EX, 25(4), 2001, pp. 517-523

Abstract

Background: The present study compared baseline local cerebral glucose utilization (LCGU) values within reward-relevant brain regions in alcohol-naive, adult male high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats from replicate lines I and 2. Methods: 2-[C-14]Deoxglucose ([C-14]2-DG) was injected (125 mu Ci/kg) intravenously during the rats' dark cycle. Timed arterial blood samples were collected over 45 min and assayed for glucose as well as [C-14]2-DG content. Rats were then decapitated; their brains quickly removed and frozen in isopentane at -50 degreesC. Coronal sections from each brain were apposed to film and exposed for 2 days. Image densities were analyzed using quantitativeautoradiography. Results: Data were collected from several key limbic (nucleus accumbens, ventral tegmental area, olfactory tubercle, amygdala, hippocampus, ventral pallidum, and septum), basal ganglia, cortical (medial prefrontal, frontal, parietal, temporal, occipital, entorhinal, pyriform, and cingulate), and subcortical (thalamus, habenula, and superior colliculus) structures. Becausethere were no significant differences between the replicates within each drinking line, data from the two replicates were combined to determine drinking line differences. When both replicate lines were combined, there were trends toward higher (approximately 15%) LCGU rates in HAD (n = 15) versus LAD (n = 16)rats within the parietal and occipital cortices, but neither of these line differences reached statistical significance (p < 0.01). Conclusions: The findings suggested that, within the HAD and LAD replicaterat lines, the selection for alcohol preference did not lead to differences in functional brain activity, as measured with the 2-DG method.

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Documento generato il 02/04/20 alle ore 00:20:06