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Titolo:
NEURONS IN THE RAT OCCIPITAL CORTEX CO-EXPRESSING THE SUBSTANCE P-RECEPTOR AND GABA - A COMPARISON BETWEEN IN-VIVO AND ORGANOTYPIC CULTURES
Autore:
ECHEVARRIA D; MATUTE C; ALBUS K;
Indirizzi:
MAX PLANCK INST BIOPHYS CHEM,DEPT NEUROBIOL,POB 2841 D-37070 GOTTINGEN GERMANY UNIV PAIS VASCO,DEPT NEUROCIENCIAS E-48940 LEIOA SPAIN
Titolo Testata:
European journal of neuroscience
fascicolo: 7, volume: 9, anno: 1997,
pagine: 1530 - 1535
SICI:
0953-816X(1997)9:7<1530:NITROC>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; CEREBRAL-CORTEX; SLICE CULTURES; VISUAL-CORTEX; IMMUNOREACTIVE NEURONS; REGIONAL DISTRIBUTION; PYRAMIDAL NEURONS; NK-1 RECEPTOR; ANTIBODIES; PEPTIDES;
Keywords:
COLOCALIZATIONS; IMMUNOHISTOCHEMISTRY; INHIBITORY INTERNEURONS; NEOCORTEX; TACHYKININ RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
D. Echevarria et al., "NEURONS IN THE RAT OCCIPITAL CORTEX CO-EXPRESSING THE SUBSTANCE P-RECEPTOR AND GABA - A COMPARISON BETWEEN IN-VIVO AND ORGANOTYPIC CULTURES", European journal of neuroscience, 9(7), 1997, pp. 1530-1535

Abstract

The morphology and the distribution of neurons expressing the NK1-receptor (NK1R) and the co-expression of gamma-aminobutyric acid (GABA) in these neurons were studied in the rat occipital cortex and in organotypic cultures (OTCs) derived from this structure. By employing immunohistochemistry, we demonstrate that the NK1R-expressing neurons are non-pyramidal neurons and cc-express GABA. Some differences were noted between in vivo and OTCs. NK1R-expressing neurons in OTCs had larger somata and longer dendrites and the proportion stained with an anti-GABA-antibody (similar to 50%) was smaller than in vivo (90%). The preferential location of NK1R-expressing neurons in layers II/III and VI, seen in vivo is not present in OTCs where these neurons distribute ratherhomogeneously through layers Il-VI. Our findings imply that in contrast to the cat and monkey, in the rat occipital cortex the effects of substance P are almost exclusively mediated via inhibitory interneurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:58:13