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Titolo:
Supernumerary outer hair cells arise external to the last row of sensory cells in the organ of corti
Autore:
Lefebvre, PP; Malgrange, B; Thiry, M; Breuskin, I; Van De Water, TR; Moonen, G;
Indirizzi:
Univ Liege, Dept Otorhinolaryngol, Lab Tissue & Cell Biol, Res Ctr Cellular & Mol Neurosci, B-4000 Liege, Belgium Univ Liege Liege Belgium B-4000 ar & Mol Neurosci, B-4000 Liege, Belgium Univ Liege, Dept Neurol, Lab Tissue & Cell Biol, Res Ctr Cellular & Mol Neurosci, B-4000 Liege, Belgium Univ Liege Liege Belgium B-4000 ar & Mol Neurosci, B-4000 Liege, Belgium Albert Einstein Coll Med, Dept Otolaryngol, Bronx, NY 10467 USA Albert Einstein Coll Med Bronx NY USA 10467 laryngol, Bronx, NY 10467 USA Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10467 USA Albert Einstein Coll Med Bronx NY USA 10467 Neurosci, Bronx, NY 10467 USA
Titolo Testata:
ACTA OTO-LARYNGOLOGICA
fascicolo: 2, volume: 121, anno: 2001,
pagine: 164 - 168
SICI:
0001-6489(200101)121:2<164:SOHCAE>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAMMALIAN COCHLEA; RETINOIC ACID; NOTCH; RAT; DIFFERENTIATION; REPLACEMENT; CULTURE; DELTA; EAR;
Keywords:
cochlea; supernumerary hair cells; transdifferentiation; cell conversion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Lefebvre, PP Ctr Neurosci Cellulaire & Mol, Pl Delcour 17, BE-4000 Liege, Belgium Ctr Neurosci Cellulaire & Mol Pl Delcour 17 Liege Belgium BE-4000
Citazione:
P.P. Lefebvre et al., "Supernumerary outer hair cells arise external to the last row of sensory cells in the organ of corti", ACT OTO-LAR, 121(2), 2001, pp. 164-168

Abstract

During the development of the mammalian inner carl the number of hair cells produced is highly regulated and remains constant throughout life. The mechanism underlying this regulation is beginning to he understood although many aspects still remain obscure. When late embryonic or early postnatal rat organs of Corti were cultured, the production of supernumerary hair cellswas observed. This overproduction of sensory cells could he modulated by the addition of several growth factors. In this study, ae examined explants of rat organs of Corti that produced supernumerary hair cells. In the supernumerary hair cell region, up to two rows of inner hair cells and five rowsof outer hair cells were observed. Morphological evaluation of these specimens revealed that less mature hair cells were located in the most externalrows of these sensory cells. When a supernumerary hair cell was produced, a supporting cell (i.e. Deiters' cell) was also produced, strongly suggesting that the conversion of a Deiters' cell into a hair cell was not the mechanism that produced these extra hair cells. Based on these results, we propose that prosensory cells located at the external edge of the organ of Corti retain a capacity to form hair cells and that it is these prosensory cells that differentiate into supernumerary hair cells and Deiters' cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/08/20 alle ore 18:52:52