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Titolo:
Effects of common topical otic preparations on the morphology of isolated cochlear outer hair cells
Autore:
Russell, PT; Church, CA; Jinn, TH; Kim, DJ; John, EO; Jung, TTK;
Indirizzi:
Loma Linda Univ, Sch Med, Div Otolaryngol Head & Neck Surg, Loma Linda, CAUSA Loma Linda Univ Loma Linda CA USA ol Head & Neck Surg, Loma Linda, CAUSA Jerry L Pettis Mem Vet Adm Med Ctr, Loma Linda, CA 92354 USA Jerry L Pettis Mem Vet Adm Med Ctr Loma Linda CA USA 92354 , CA 92354 USA
Titolo Testata:
ACTA OTO-LARYNGOLOGICA
fascicolo: 2, volume: 121, anno: 2001,
pagine: 135 - 139
SICI:
0001-6489(200101)121:2<135:EOCTOP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROUND WINDOW MEMBRANE; SUPPURATIVE OTITIS-MEDIA; CIPROFLOXACIN OTOTOXICITY; PERMEABILITY; NEOMYCIN; EAR; PENETRATION; GENTAMICIN; PERILYMPH; HEARING;
Keywords:
chinchilla; Ciloxan; Cipro HC; Floxin; isolated outer hair cells; otic drops; ototoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Jung, TTK 11790 Pecan Way, Loma Linda, CA 92354 USA 11790 Pecan Way Loma Linda CA USA 92354 oma Linda, CA 92354 USA
Citazione:
P.T. Russell et al., "Effects of common topical otic preparations on the morphology of isolated cochlear outer hair cells", ACT OTO-LAR, 121(2), 2001, pp. 135-139

Abstract

Otic drops are commonly used not only for otitis externa but also for otorrhea in the presence of tympanostomy tube or tympanic membrane perforation. Many studies have demonstrated the ototoxicity of common otic preparationssuch as Cortisporin(R) otic drops. Recent studies have suggested the use of fluoroquinolone antibiotic drops as an alternative owing to their excellent antimicrobial coverage and no ototoxic effect. The purpose of this studywas to assess the relative ototoxicity of four common otic preparations bydirect exposure to isolated cochlear outer hair cells (OHCs). OHCs from adult chinchilla cochlea were exposed to standard bathing solution (control),Cortisporin, Cipro HC(R), Ciloxan(R), and Floxin(R). The cells were observed using an inverted microscope, and the images recorded in digital still-frame and video, and analyzed on the Image Pro-Plus(R) 3.0 program. As measured by time to cell death and change in morphology of OHCs, Cortisporin wasmost toxic to OHCs. Among the fluoroquinolone drops, Floxin was more toxicthan Ciloxan or Cipro HC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 15:22:31