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Titolo:
Biological and genetic markers of sporadic Alzheimer's disease
Autore:
Engelborghs, S; De Deyn, PP;
Indirizzi:
Middelheim Gen Hosp, Dept Neurol, Antwerp, Belgium Middelheim Gen Hosp Antwerp Belgium Hosp, Dept Neurol, Antwerp, Belgium Univ Antwerp, Lab Neurochem & Behav, Dept Neurol, Antwerp, Belgium Univ Antwerp Antwerp Belgium hem & Behav, Dept Neurol, Antwerp, Belgium Middelheim Gen Hosp, Memory Clin, Antwerp, Belgium Middelheim Gen Hosp Antwerp Belgium Hosp, Memory Clin, Antwerp, Belgium
Titolo Testata:
ACTA MEDICA OKAYAMA
fascicolo: 2, volume: 55, anno: 2001,
pagine: 55 - 63
SICI:
0386-300X(200104)55:2<55:BAGMOS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPEROXIDE-DISMUTASE ACTIVITY; AMINO-ACID-CONCENTRATIONS; HUMAN CEREBROSPINAL-FLUID; ANOMALOUS MOLECULAR-FORM; NEURONAL THREAD PROTEIN; APOLIPOPROTEIN-E; SENILE DEMENTIA; TAU-PROTEIN; NEUROFIBRILLARY CHANGES; PARKINSONS-DISEASE;
Keywords:
Alzheimer's disease; dementia; marker; neurochemistry; cerebrospinal fluid;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: De Deyn, PP Middelheim Gen Hosp, Dept Neurol, Antwerp, Belgium Middelheim Gen Hosp Antwerp Belgium eurol, Antwerp, Belgium
Citazione:
S. Engelborghs e P.P. De Deyn, "Biological and genetic markers of sporadic Alzheimer's disease", ACT MED OKA, 55(2), 2001, pp. 55-63

Abstract

With the development of new treatments, there is an increasing need for early diagnosis of sporadic Alzheimer's disease. Therefore, biological markers allowing positive diagnosis early in the course of the disease are highlydesirable. Cerebrospinal fluid levels of protein tau were shown to be significantly increased in patients with Alzheimer's disease, Although sensitivity is high, poor specificity limits the diagnostic value of this marker. The same is true for the 42 amino acid isoform of beta -amyloid protein thatis significantly decreased in cerebrospinal fluid of Alzheimer's disease patients. However, combining both markers could improve specificity at leastallowing differentiation between Alzheimer's disease, normal ageing and depressive pseudodementia. Other biological markers such as cerebrospinal fluid levels of neurotransmitters, cytokines or superoxide dismutase were shown to have even less diagnostic value, The apolipoprotein epsilon4 allele isa risk factor for Alzheimer's disease but not a diagnostic marker as many individuals who inherit epsilon4 do not develop the disease. Till now, a single diagnostic marker allowing discrimination between Alzheimer's disease and other dementias does not exist. Combined cerebrospinal fluid levels of beta -amyloid protein and tau protein might be used as a marker that helps discriminating Alzheimer's disease from normal ageing and depression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:32:25