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Titolo:
Survival of retinal ganglion cells after transection of the optic nerve inadult cats: A quantitative study within two weeks
Autore:
Watanabe, M; Inukai, N; Fukuda, Y;
Indirizzi:
Inst Dev Res, Dept Physiol, Kasugai, Aichi 4800392, Japan Inst Dev Res Kasugai Aichi Japan 4800392 l, Kasugai, Aichi 4800392, Japan Osaka Univ, Grad Sch Med, Dept Physiol & Biosignaling, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 gnaling, Suita, Osaka 5650871, Japan
Titolo Testata:
VISUAL NEUROSCIENCE
fascicolo: 1, volume: 18, anno: 2001,
pagine: 137 - 145
SICI:
0952-5238(200101/02)18:1<137:SORGCA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROTROPHIC FACTOR BDNF; IN-VIVO; CENTRAL PROJECTIONS; PERIPHERAL-NERVE; X-CELLS; AXOTOMY; RAT; REGENERATION; NUMBER; GDNF;
Keywords:
retinal ganglion cell; axotomy; survival; intracellular injection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Watanabe, M Inst Dev Res, Dept Physiol, Kasugai, Aichi 4800392, Japan InstDev Res Kasugai Aichi Japan 4800392 Aichi 4800392, Japan
Citazione:
M. Watanabe et al., "Survival of retinal ganglion cells after transection of the optic nerve inadult cats: A quantitative study within two weeks", VIS NEUROSC, 18(1), 2001, pp. 137-145

Abstract

We have previously reported that a small number of retinal ganglion cells (RGCs) of adult cats survive 2 months after transection of the optic nerve (ON) and that alpha cells have the greatest ability to survive among different types of RGCs (Watanabe et al., 1995). Here we report the time course of RGC survival within 15 days after ON transection using retrograde labeling with Oil injected into the bilateral lateral geniculate nuclei of cats. The density of DiI-labeled RGCs in the central retina as well as in the periphery did not change until day 3 after ON transection, then decreased rapidly, to 43% of the original density on day 7, and falling to 19% by day 14. We then intracellularly injected Lucifer yellow into the DiI-labeled RGCs to examine the difference in the time course between surviving alpha and beta cells. Similar to the density change in total surviving RGCs, the proportion of surviving beta cells did not change until day 3, then decreased rapidly to 65% of the original density on day 4, falling to 12% by day 14. By contrast, 64% of alpha cells survived for 14 days after axotomy. Analysis ofregression lines for survival time courses indicated that death of beta cells was characterized with a rapid period phase from day 3 to day 7 after axotomy whereas that of alpha cells lacked it. Axon-like sprouting from surviving beta cells was first recognized in the nerve fiber layer on day 3, and were later more conspicuous.

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Documento generato il 23/09/20 alle ore 11:52:56