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Titolo:
Role of GABA(A)-mediated inhibition in controlling the responses of regular spiking cells in turtle visual cortex
Autore:
Mancilla, JG; Ulinski, PS;
Indirizzi:
Univ Chicago, Dept Organismal Biol & Anat, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 smal Biol & Anat, Chicago, IL 60637 USA Univ Chicago, Comm Neurobiol, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 , Comm Neurobiol, Chicago, IL 60637 USA
Titolo Testata:
VISUAL NEUROSCIENCE
fascicolo: 1, volume: 18, anno: 2001,
pagine: 9 - 24
SICI:
0952-5238(200101/02)18:1<9:ROGIIC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY SOMATOSENSORY CORTEX; SPINY STELLATE NEURONS; CAT STRIATE CORTEX; RAT FRONTAL-CORTEX; RECEPTIVE-FIELD PROPERTIES; CORTICAL-NEURONS; PYRAMIDAL NEURONS; GABA RECEPTOR; MORPHOLOGICAL-CHARACTERISTICS; PHYSIOLOGICAL-PROPERTIES;
Keywords:
neocortex; pyramidal cells; interneurons; excitatory postsynaptic potentials; inhibitory postsynaptic potentials;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Ulinski, PS Univ Chicago, Dept Organismal Biol & Anat, 1027 E 57th St, Chicago, IL 60637 USA Univ Chicago 1027 E 57th St Chicago IL USA 60637 IL 60637 USA
Citazione:
J.G. Mancilla e P.S. Ulinski, "Role of GABA(A)-mediated inhibition in controlling the responses of regular spiking cells in turtle visual cortex", VIS NEUROSC, 18(1), 2001, pp. 9-24

Abstract

The visual cortex of freshwater turtles contains pyramidal cells, which have a regular spiking IRS) firing pattern, and several categories of aspiny,inhibitory interneurons. The interneurons show diverse firing patterns, including the fast spilling (FS) pattern. Postsynaptic potentials (PSPs) evoked in FS cells by visual stimulation of the retina reach their peak amplitudes as much as 200 ms before PSPs in RS cells (Mancilla et al., 1998). FS cells could, consequently, control the amplitudes of light-evoked PSPs in RScells by producing disynaptic, feedforward inhibitory postsynaptic potentials (IPSPs) that overlap in time with geniculocortical excitatory postsynaptic potentials (EPSPs). Since FS cells receive recurrent, excitatory inputsfrom RS cells, they could also control the amplitudes of light-evoked PSPsin RS cells,via polysynaptic, feedback inhibition. The ill vitro geniculocortical preparation of Pseudemys scripta was used to characterize the temporal relationships of EPSPs and IPSPs produced in RS cells by electrical activation of geniculate afferents and by diffuse light flashes presented to the retina. GABA(A) receptor-mediated inhibition was blocked using extracellular application of bicuculline (3.5 mM) or intracellular perfusion of picrotoxin (1 muM) in individual RS cells, Electrical stimulation of thalamic afferents produced compound PSPs. Blockade of GABA, receptor-mediated IPSPs with either bicuculline or picrotoxin provided evidence for both early and late IPSPs in RS cells. Analysis of the apparent reversal potentials of light-evoked PSPs indicated the existence of early IPSPs during the first 140-300 ms following light onset. Light responses of cells perfused with picrotoxin diverged From control light responses at about 300 ms after light onset and had maximum amplitudes that were significantly different from controllight responses. These experiments indicate that the responses of RS cellsto both electrical and natural stimulation of geniculate: afferents are controlled by both early and late IPSPs, consistent with activation of both feedforward and feedback pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:24:09