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Titolo:
On-bipolar cells and depolarising third-order neurons as the origin of theERG-b-wave in the RCS rat
Autore:
Wurziger, K; Lichtenberger, T; Hanitzsch, R;
Indirizzi:
Univ Leipzig, Carl Ludwig Inst Physiol, D-04103 Leipzig, Germany Univ Leipzig Leipzig Germany D-04103 t Physiol, D-04103 Leipzig, Germany
Titolo Testata:
VISION RESEARCH
fascicolo: 8, volume: 41, anno: 2001,
pagine: 1091 - 1101
SICI:
0042-6989(200104)41:8<1091:OCADTN>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISOLATED RABBIT RETINA; SOURCE-DENSITY ANALYSIS; PIGMENT-EPITHELIUM; POTASSIUM CHANGES; FIELD POTENTIALS; 2-AMINO-4-PHOSPHONOBUTYRIC ACID; MAMMALIAN RETINA; EXTRACELLULAR-K+; HORIZONTAL CELLS; ROYAL-COLLEGE;
Keywords:
amacrine cells; bipolar cells; ERG b-wave; potassium; RCS rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Hanitzsch, R Univ Leipzig, Carl Ludwig Inst Physiol, Liebigstr 27, D-04103Leipzig, Germany Univ Leipzig Liebigstr 27 Leipzig Germany D-04103 g, Germany
Citazione:
K. Wurziger et al., "On-bipolar cells and depolarising third-order neurons as the origin of theERG-b-wave in the RCS rat", VISION RES, 41(8), 2001, pp. 1091-1101

Abstract

In the retinas of Royal College of Surgeons (RCS) rats light induces an increase in distal extracellular potassium irrespective of the age, between days 19-24 and days 29-35 postpartum, but by days 29-35 the ERG b-wave has become reduced. The synaptic blocker 2-amino-4-phosphonobutyric acid (APB) causes the abolition of both the b-wave and the potassium increase at any age. MgCl2 greatly reduces the b-wave at all ages and abolishes the potassiumincrease in older rats, but in younger rats the potassium increase is enlarged. Since this increase occurs in the absence of the b-wave it is unlikely that the on-bipolar cells are the only sources of the b-wave. Because theNMDA receptor blocker ketamine reduces the b-wave, third order neurons, which possess NMDA receptors, could contribute to the b-wave. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:59:35