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Titolo:
Increased hypoxia correlates with increased expression of the angiogenesismarker vascular endothelial growth factor in human prostate cancer
Autore:
Cvetkovic, D; Movsas, B; Dicker, AP; Hanlon, AL; Greenberg, RE; Chapman, JD; Hanks, GE; Tricoli, JV;
Indirizzi:
Fox Chase Canc Ctr, Dept Radiat Oncol, Philadelphia, PA 19111 USA Fox Chase Canc Ctr Philadelphia PA USA 19111 , Philadelphia, PA 19111 USA Jefferson Canc Ctr, Dept Radiat Oncol, Philadelphia, PA USA Jefferson CancCtr Philadelphia PA USA adiat Oncol, Philadelphia, PA USA Fox Chase Canc Ctr, Dept Surg, Philadelphia, PA 19111 USA Fox Chase Canc Ctr Philadelphia PA USA 19111 , Philadelphia, PA 19111 USA
Titolo Testata:
UROLOGY
fascicolo: 4, volume: 57, anno: 2001,
pagine: 821 - 825
SICI:
0090-4295(200104)57:4<821:IHCWIE>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCIBLE FACTOR 1-ALPHA; SQUAMOUS-CELL CARCINOMA; NEGATIVE BREAST-CANCER; FACTOR VEGF EXPRESSION; IN-VITRO EXPRESSION; TUMOR ANGIOGENESIS; UTERINE CERVIX; METASTASIS; ASSOCIATION; PROGRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Tricoli, JV Fox Chase Canc Ctr, Dept Radiat Oncol, 7701 Burholme Ave, Philadelphia, PA19111 USA Fox Chase Canc Ctr 7701 Burholme Ave Philadelphia PA USA 19111
Citazione:
D. Cvetkovic et al., "Increased hypoxia correlates with increased expression of the angiogenesismarker vascular endothelial growth factor in human prostate cancer", UROLOGY, 57(4), 2001, pp. 821-825

Abstract

Objectives. To test the hypothesis that increasing levels of hypoxia are associated with increased expression of vascular endothelial growth factor (VEGF) in prostate cancer by correlating the level of median tissue oxygenation in human prostate tumors with the immunohistochemically determined level of VEGF expression. Methods. Custom-made Eppendorf oxygen microelectrodes were used to quantitate the pO(2) levels in prostate tumors of 13 men undergoing radical prostatectomy. All pO(2) measurements were performed under fluorine-based generalanesthesia. Paraffin-embedded tumor tissue from these men was analyzed to measure the level of VEGF expression by immunohistochemical staining. The significance of the associations between the pO(2) levels and VEGF staining were determined by the Pearson correlations. Results. The range of the median pO(2) levels (based on between 97 and 129individual measurements) among 13 prostate tumors was 0.5 to 44.9 mm Hg. The blinded comparison of pO(2) levels and VEGF staining intensity demonstrated a significant correlation between increasing hypoxia and the percentageof cells staining positive for VEGF (r = -0.721, P = 0.005). This correlation was also significant when pO(2) levels were compared with the overall immunoreactive score, which takes into account staining intensity (r = -0.642, P = 0.018). Conclusions. To our knowledge, this is the first study demonstrating a significant association between increasing levels of hypoxia and increased expression of the angiogenesis marker VEGF in human prostate carcinoma. The results of our study further support the exploration of antiangiogenesis strategies for the treatment of human prostate cancer. UROLOGY 57: 821-825, 2001. (C) 2001, Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 08:36:57