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Titolo:
Neurovascular coupling and cerebral autoregulation can be described in terms of a control system
Autore:
Rosengarten, B; Huwendiek, O; Kaps, M;
Indirizzi:
Univ Giessen, Fac Med, Dept Neurol, Giessen, Germany Univ Giessen Giessen Germany en, Fac Med, Dept Neurol, Giessen, Germany Univ Lubeck, Dept Informat Technol, Lubeck, Germany Univ Lubeck Lubeck Germany beck, Dept Informat Technol, Lubeck, Germany
Titolo Testata:
ULTRASOUND IN MEDICINE AND BIOLOGY
fascicolo: 2, volume: 27, anno: 2001,
pagine: 189 - 193
SICI:
0301-5629(200102)27:2<189:NCACAC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRANIAL DOPPLER; BLOOD-FLOW; VELOCITY; ARTERIAL; RECORDINGS; ULTRASOUND; DYNAMICS; PRESSURE; HUMANS;
Keywords:
cerebral blood flow; transcranial Doppler sonography; diagnostic imaging; metabolism; autoregulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Kaps, M Steg 14, D-35385 Giessen, Germany Steg 14 Giessen Germany D-35385 teg 14, D-35385 Giessen, Germany
Citazione:
B. Rosengarten et al., "Neurovascular coupling and cerebral autoregulation can be described in terms of a control system", ULTRASOUN M, 27(2), 2001, pp. 189-193

Abstract

Neurovascular coupling and cerebral autoregulation are important and fast mechanisms for maintaining an adequate blood supply to the brain. It was suggested that both mechanisms follow a common control system. The aim of ourstudy was to describe neurovascular coupling and cerebral autoregulation in mathematical terms of a control system and to test the aforementioned hypothesis. We analyzed the input-output dynamics of neurovascular coupling (flicker light test) and cerebral autoregulation (leg cuff test) in terms of a control system, and compared both systems. A transcranial Doppler device was used to measure continuously the blood flow velocity changes in young healthy volunteers who lacked vascular risk factors. For both tests, a control system model with only four parameters was sufficient to allow the vascular reaction to be described in all (rate time, undamped natural angular frequency, attenuation, gain). All parameters were identical for both controlsystems, except for gain, which is not directly comparable because, in theflicker light test, input function was not measured but assumed as a unit step function in each volunteer. This new method permits description of theregulation of cerebral blood Bow using a control loop with four parameters. For the first time, these parameters allowed a demonstration that cerebral autoregulation and neurovascular coupling could be governed by the same control system. (C) 2001 World Federation for Ultrasound in Medicine & Biology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:10:21