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Titolo:
DNA mismatch repair: The hands of a genome guardian
Autore:
Hopfner, KP; Tainer, JA;
Indirizzi:
Scripps Clin & Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 iol, La Jolla, CA 92037 USA Scripps Clin & Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 iol, La Jolla, CA 92037 USA Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA USA Lawrence Berkeley Lab Berkeley CA USA ab, Div Life Sci, Berkeley, CA USA
Titolo Testata:
STRUCTURE
fascicolo: 12, volume: 8, anno: 2000,
pagine: R237 - R241
SICI:
0969-2126(200012)8:12<R237:DMRTHO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSLOCATION MECHANISM; REPLICATION FIDELITY; STRUCTURAL BIOLOGY; CRYSTAL-STRUCTURE; MOLECULAR SWITCH; ATP HYDROLYSIS; PROTEIN MUTS; COMPLEX; CANCER; SUSCEPTIBILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Tainer, JA Scripps Clin & Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 la, CA 92037 USA
Citazione:
K.P. Hopfner e J.A. Tainer, "DNA mismatch repair: The hands of a genome guardian", STRUCTURE, 8(12), 2000, pp. R237-R241

Abstract

DNA mismatch repair (MMR) is initiated when the MutS protein recognizes damaged DNA. Crystal structures of MutS bound to mispaired and unpaired DNA show how MutS distinguishes damaged from undamaged DNA and explain how a broad variety of DNA mismatch lesions can be detected. The structures suggest mechanisms for the ATP-induced structural regulation of multistep DNA repair processes.

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Documento generato il 22/09/20 alle ore 18:24:39