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Titolo:
Lifestyles and mental health status are associated with natural killer cell and lymphokine-activated killer cell activities
Autore:
Morimoto, K; Takeshita, T; Inoue-Sakurai, C; Maruyama, S;
Indirizzi:
Osaka Univ, Grad Sch Med, Dept Social & Environm Med, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 onm Med, Suita, Osaka 5650871, Japan
Titolo Testata:
SCIENCE OF THE TOTAL ENVIRONMENT
fascicolo: 1-3, volume: 270, anno: 2001,
pagine: 3 - 11
SICI:
0048-9697(20010410)270:1-3<3:LAMHSA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTO-TOXICITY; LIFE-STYLES; CANCER; BLOOD; IMMUNITY; SMOKING; STRESS; DISEASE;
Keywords:
NK cell activity; LAK cell activity; lifestyle; smoking; mental health;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Morimoto, K Osaka Univ, Grad Sch Med, Dept Social & Environm Med, F1,2-2 Yamada Oka, Suita, Osaka 5650871, Japan Osaka Univ F1,2-2 Yamada Oka Suita Osaka Japan 5650871 , Japan
Citazione:
K. Morimoto et al., "Lifestyles and mental health status are associated with natural killer cell and lymphokine-activated killer cell activities", SCI TOTAL E, 270(1-3), 2001, pp. 3-11

Abstract

We investigated the association of lifestyle and mental health status withnatural killer (NK) cell and lymphokine-activated killer (LAK) cell activities in healthy males. NK cell activity was determined in 105 male workers and LAK cell activity was determined in 54 male workers, peripheral blood was obtained from each subject and peripheral blood mononuclear cells (PBMC)were isolated from the blood. These PBMC were used as effector cells. LAK cells were generated by incubation of PBMC with interleukin-2 for 72 h. NK cell activity against NK-sensitive K562 cells and LAK cell activity againstNK-resistant Raji cells were examined by Cr-51 release assay. Overall lifestyles were evaluated according to the answers on a questionnaire regardingeight health practices (cigarette smoking, alcohol consumption, eating breakfast, hours of sleep, hours of work, physical exercise, nutritional balance, mental stress). Subjects with a good overall lifestyle showed significantly higher NK cell (P< 0.05) and LAK cell (P < 0.05) activities than thosewith a poor overall lifestyles. Among eight lifestyle factors, cigarette smoking has relatively strong effects on NK cell and LAK cell activities. Subjects who complained of unstable mental status had significantly lower NK cell activity than those who reported stable mental status. When subjects were divided into four groups by lifestyle and mental health status, subjects who had poor or moderate lifestyle and reported unstable mental status showed the lowest NK cell activity and subjects who had good lifestyle and reported stable mental status showed the highest NK cell activity among four groups. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 12:18:18