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Titolo:
Saccadic and smooth-pursuit eye movements in deficit and non-deficit schizophrenia
Autore:
Nkam, I; Thibaut, F; Denise, P; Van Der Elst, A; Segard, L; Brazo, P; Menard, JF; Thery, S; Halbeck, I; Delamilleure, P; Vasse, T; Etard, O; Dollfus, S; Champion, D; Levillain, D; Petit, M;
Indirizzi:
Univ Med Rouen, Unite Rech Mixte, INSERM, EPI 9906, F-76183 Rouen, France Univ Med Rouen Rouen France F-76183 ERM, EPI 9906, F-76183 Rouen, France Univ Rouen, JE 2014, F-76183 Rouen, France Univ Rouen Rouen France F-76183 iv Rouen, JE 2014, F-76183 Rouen, France Univ Rouen, Programme Hosp Rech Clin, F-76183 Rouen, France Univ Rouen Rouen France F-76183 me Hosp Rech Clin, F-76183 Rouen, France
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1, volume: 48, anno: 2001,
pagine: 145 - 153
SICI:
0920-9964(20010301)48:1<145:SASEMI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRACKING DYSFUNCTION; NONDEFICIT FORMS; VOLUNTARY CONTROL; CORTICAL CONTROL; NEGATIVE SYMPTOMS; BRAIN MORPHOLOGY; ABNORMALITIES; PERFORMANCE; ATTENTION; DISORDER;
Keywords:
antisaccade paradigm; deficit syndrome; schizophrenia; smooth pursuit; Wisconsin Card Sorting Test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Thibaut, F CHRU C Nicolle, Unite Psychiat, 1 Rue de Germont, F-76031 Rouen, France CHRU C Nicolle 1 Rue de Germont Rouen France F-76031 n, France
Citazione:
I. Nkam et al., "Saccadic and smooth-pursuit eye movements in deficit and non-deficit schizophrenia", SCHIZOPHR R, 48(1), 2001, pp. 145-153

Abstract

We have analyzed eye movement performances in schizophrenics showing primary negative or deficit symptoms (n = 16) and non-deficit schizophrenics (n = 55), and compared them with those of controls (n = 34) in order to study the relationships between negative symptoms and eye movement abnormalities. Patients were subtyped into deficit and non-deficit subgroups using the Schedule for the Deficit Syndrome. Three oculomotor paradigms were used: smooth pursuit, a reflexive saccade paradigm and an antisaccadic task. The smooth pursuit gain was significantly decreased land the rate of catch-up saccades increased in schizophrenics as compared with controls, but no difference was observed between patient groups. In the reflexive saccade paradigm, no difference was found between controls and patients, except for latency in deficit patients. Tn the antisaccade paradigm, the number of errors and the latency of successful antisaccades were significantly increased in schizophrenics as compared with controls. The latency of successful antisaccades in both directions was significantly increased in deficit patientsas compared with non-deficit patients. The latency of rightward successfulantisaccades was significantly increased as compared with the latency of leftward antisaccades in deficit patients only. However, when patients were classified into negative and non-negative groups using the PANSS, no difference was found in the antisaccade paradigm. Smooth pursuit impairment does not seem to depend on the primary enduring negative symptoms. In deficit schizophrenics, the abnormalities observed in the antisaccadic task are consistent with prefrontal dysfunction, and may suggest parietal lobe dysfunction as well. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 26/01/20 alle ore 22:20:05