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Titolo:
Evidence for a mitochondrial oxidative phosphorylation defect in brains from patients with schizophrenia
Autore:
Maurer, I; Zierz, S; Moller, HJ;
Indirizzi:
Univ Jena, Dept Psychiat, D-07740 Jena, Germany Univ Jena Jena Germany D-07740 ena, Dept Psychiat, D-07740 Jena, Germany Univ Halle Wittenberg, Dept Neurol, Halle, Germany Univ Halle Wittenberg Halle Germany enberg, Dept Neurol, Halle, Germany Univ Munich, Dept Psychiat, D-8000 Munich, Germany Univ Munich Munich Germany D-8000 Dept Psychiat, D-8000 Munich, Germany
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1, volume: 48, anno: 2001,
pagine: 125 - 136
SICI:
0920-9964(20010301)48:1<125:EFAMOP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; RESPIRATORY-CHAIN FUNCTION; C-OXIDASE ACTIVITY; PREFRONTAL CORTEX; SKELETAL-MUSCLE; FRONTAL LOBES; COMPLEX-I; RAT-BRAIN; DISEASE; NEUROLEPTICS;
Keywords:
cytochrome c oxidase; energy metabolism; mitochondria; oxidative phosphorylation; respiratory chain; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Maurer, I Univ Jena, Dept Psychiat, Philosophenweg 3, D-07740 Jena, Germany Univ Jena Philosophenweg 3 Jena Germany D-07740 0 Jena, Germany
Citazione:
I. Maurer et al., "Evidence for a mitochondrial oxidative phosphorylation defect in brains from patients with schizophrenia", SCHIZOPHR R, 48(1), 2001, pp. 125-136

Abstract

In-vivo imaging studies and post-mortem studies have demonstrated an impairment of energy metabolism in brains of patients with schizophrenia. Decreased oxidative metabolism has been consistently documented in the frontal lobes. However, the biochemical basis of these changes is unclear. The changes could be caused by reduced requirement of the cells for metabolic energy or an abnormality in energy generation. Neurons generate energy through therespiratory chain in the mitochondria. The respiratory chain consists of five enzyme complexes (I-V). The purpose of the present study was to assess mitochondrial function and test the hypothesis of an underlying oxidative phosphorylation defect in schizophrenia. We analysed spectrophotometrically post-mortem brain specimens of frontal cortex, temporal cortex, basal ganglia, and cerebellum of 12 patients who met the DSM-TV criteria for schizophrenia and of 13 healthy controls for the specific activities of respiratory chain enzymes in the mitochondria. The major finding was that the activity of complex IV was significantly reduced in the frontal cortex (40.9 +/- 6.7vs. 87.3 +/- 12, P = 0.003) and in the temporal cortex (39.5 +/- 6.8 vs. 78 +/- 10.8, P = 0.006) of schizophrenics. In addition, the activity of complexes I + III was significantly reduced in the temporal cortex (2.2 +/- 0.6vs. 4.4 +/- 0.5, P = 0.01) and basal ganglia (1.6 +/- 0.5 vs. 3.4 +/- 0.3,P = 0.015) in schizophrenia. All other enzyme activities showed no differences to healthy controls. The results confirm a defect of oxidative phosphorylation in brains from patients with schizophrenia, which may contribute to impaired energy generation. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 06/04/20 alle ore 21:47:38