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Titolo:
Neuropsychological change in schizophrenia after 6 weeks of clozapine
Autore:
Purdon, SE; Labelle, A; Boulay, L;
Indirizzi:
Univ Alberta, Dept Psychiat, Edmonton, AB, Canada Univ Alberta Edmonton AB Canada rta, Dept Psychiat, Edmonton, AB, Canada Univ Ottawa, Dept Psychiat, Ottawa, ON K1N 6N5, Canada Univ Ottawa OttawaON Canada K1N 6N5 Psychiat, Ottawa, ON K1N 6N5, Canada Royal Ottawa Hosp, Schizophrenia Program, Ottawa, ON K1Z 7K4, Canada RoyalOttawa Hosp Ottawa ON Canada K1Z 7K4 am, Ottawa, ON K1Z 7K4, Canada Carleton Univ, Ottawa, ON K1S 5B6, Canada Carleton Univ Ottawa ON Canada K1S 5B6 n Univ, Ottawa, ON K1S 5B6, Canada
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1, volume: 48, anno: 2001,
pagine: 57 - 67
SICI:
0920-9964(20010301)48:1<57:NCISA6>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PATIENTS RECEIVING CLOZAPINE; PSYCHIATRIC-SYMPTOMS; COGNITIVE FUNCTIONS; PERFORMANCE; NEUROLEPTICS; IMPAIRMENTS; RISPERIDONE; IMPROVEMENT; REDUCTION; DEFICITS;
Keywords:
clozapine; cognition; neuroleptic; neuropsychology; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Purdon, SE Alberta Hosp Edmonton, Neuropsychol 9 Bldg,Box 307,17480 Ft Rd,Edmonton, AB, Canada Alberta Hosp Edmonton Neuropsychol 9 Bldg,Box 307,17480 Ft Rd Edmonton AB Canada
Citazione:
S.E. Purdon et al., "Neuropsychological change in schizophrenia after 6 weeks of clozapine", SCHIZOPHR R, 48(1), 2001, pp. 57-67

Abstract

Neuropsychological change after 6 weeks of clozapine treatment was examined in 18 treatment-refractory patients to test anticipated domain-specific cognitive improvements. The first aim of this study was to test the assumption that increased homogeneity of sample and treatment would yield an experimental design with sufficient sensitivity to detect general intellectual changes with clozapine that were not apparent in one previous investigation. The second aim was to test predictions derived from a domain-specific review of all other investigations with clozapine suggesting salient gains on tests sensitive to motor and mental speed, visual spatial manipulation, and new learning of verbal material. The results showed that the comprehensive neuropsychological test battery was sensitive to general cognitive changes with clozapine, and supported the hypothesized domain-specific gains on tests of motor and mental speed, visual spatial manipulation and new verbal learning. Novel gains were also apparent on tests of new learning with nonverbal material. The results are discussed in relation to aspects of experimental design necessary for the evaluation of prospective medication-induced changes in cognitive skill, particularly in future investigations designed todifferentiate between second-generation antipsychotic medications. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:11:11