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Titolo:
Minocycline-induced lupus: clinical features and response to rechallenge
Autore:
Lawson, TM; Amos, N; Bulgen, D; Williams, BD;
Indirizzi:
Univ Wales Hosp, Dept Rheumatol, Cardiff CF14 4XN, S Glam, Wales Univ Wales Hosp Cardiff S Glam Wales CF14 4XN iff CF14 4XN, S Glam, Wales Countess Chester Hosp, Dept Rheumatol, Chester CH2 1UL, Cheshire, England Countess Chester Hosp Chester Cheshire England CH2 1UL Cheshire, England
Titolo Testata:
RHEUMATOLOGY
fascicolo: 3, volume: 40, anno: 2001,
pagine: 329 - 335
SICI:
1462-0324(200103)40:3<329:MLCFAR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRUG-RELATED LUPUS; PLACEBO-CONTROLLED TRIAL; RHEUMATOID-ARTHRITIS; DOUBLE-BLIND; AUTOIMMUNE HEPATITIS; ERYTHEMATOSUS; ANTIBODIES; PNEUMONITIS;
Keywords:
minocycline; CRP; SLE; drug-induced lupus; rechallenge;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Lawson, TM Univ Wales Hosp, Dept Rheumatol, Cardiff CF14 4XN, S Glam, Wales Univ Wales Hosp Cardiff S Glam Wales CF14 4XN N, S Glam, Wales
Citazione:
T.M. Lawson et al., "Minocycline-induced lupus: clinical features and response to rechallenge", RHEUMATOLOG, 40(3), 2001, pp. 329-335

Abstract

Objective. To describe the spectrum of clinical features in patients with minocycline-induced lupus (MIL) and determine their response to rechallenge. Methods. The clinical features and laboratory findings of 23 patients withMIL were recorded. Ten patients were rechallenged, and their. C-reactive protein (CRP) levels were monitored. Results. All subjects complained of polyarthralgia; three had metacarpophalangeal and proximal interphalangeal joint synovitis and one had bilateral knee effusions. Elevated hepatic transaminases were noted in eight subjects. Cutaneous vasculitis was a feature ill two cases. None had renal or central nervous system disease, although five patients complained of impaired concentration and Door memory and a single patient had a peripheral sensory neuropathy. The following serological abnormalities were detected: antinuclear antibodies (19/23 patients); antibodies to double-stranded DNA (4/23); perinuclear antineutrophil cytoplasmic antibodies (10/15); IgG anti-cardiolipin antibodies (6/23); hypergammaglobulinaemia (12/19). Anti-histone antibodies were negative in 9/9 cases. Rechallenge resulted in rapid recurrence of symptoms and elevation of CRP levels. Conclusion. MIL is associated with a wide spectrum of clinical and serological features. The diagnosis can be confirmed by rechallenge, which resultsin rapid reappearance of symptoms and a rise in CRP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:33:32