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Titolo:
Assessment of pituitary gonadotropin release to gonadotropin releasing hormone/thyroid-stimulating hormone stimulation in women with systemic sclerosis
Autore:
La Montagna, G; Baruffo, A; Pasquali, D; Bellastella, A; Tirri, G; Sinisi, AA;
Indirizzi:
Univ Naples 2, Inst Clin Med, Cattedra & Div Reumatol, I-80131 Naples, Italy Univ Naples 2 Naples Italy I-80131 & Div Reumatol, I-80131 Naples, Italy Univ Naples 2, Div Rheumatol, I-80131 Naples, Italy Univ Naples 2 NaplesItaly I-80131 Div Rheumatol, I-80131 Naples, Italy Univ Naples 2, Inst Endocrinol, I-80131 Naples, Italy Univ Naples 2 Naples Italy I-80131 nst Endocrinol, I-80131 Naples, Italy
Titolo Testata:
RHEUMATOLOGY
fascicolo: 3, volume: 40, anno: 2001,
pagine: 310 - 314
SICI:
1462-0324(200103)40:3<310:AOPGRT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUPUS-ERYTHEMATOSUS; DISEASE-ACTIVITY; PROLACTIN; PREGNANCY; HYPERPROLACTINEMIA; SCLERODERMA; CULTURES; INVITRO;
Keywords:
systemic sclerosis; prolactin; gonadotropins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: La Montagna, G Univ Naples 2, Inst Clin Med, Cattedra & Div Reumatol, Via S Pansini 5, I-80131 Naples, Italy Univ Naples 2 Via S Pansini 5 Naples Italy I-80131 , Italy
Citazione:
G. La Montagna et al., "Assessment of pituitary gonadotropin release to gonadotropin releasing hormone/thyroid-stimulating hormone stimulation in women with systemic sclerosis", RHEUMATOLOG, 40(3), 2001, pp. 310-314

Abstract

Objective. To evaluate basal and dynamic levels of pituitary gonadotropin release in female systemic sclerosis (SSc) patients of childbearing age andin post-menopausal SSc patients. Methods. We performed stimulation tests for gonadotropin-releasing hormone(GnRH) and thyroid-stimulating hormone (TRH) during the early follicular phase in 12 women of childbearing age [mean age (S.E.M.) 34.8 (2.4) yr] withSSc to determine serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LI-I) and prolactin. Blood samples were also obtained from six post-menopausal women with SSc [mean age 46.8 (2.3) yr], after TRH stimulation; only serum prolactin concentration was determined, becauseelevated basal concentrations of FSH and LH were expected, Hormone concentrations were estimated by radioimmunoassay. Comparisons were made with healthy control women matched for age and reproductive status. Results. In SSc patients of childbearing age, basal FSH, LII and oestradiol (E-2) levels were not significantly different from those in controls, whereas basal prolactin concentration was significantly higher than in controls (P = 0.0001). After the stimulation test, the peak concentrations of FSH (P = 0.0001) and prolactin (P < 0.0001) were significantly higher than in controls. The net integrated response curves [net area under the curve (AUC)] for FSH and LII did not differ significantly between SSc patients and controls. On the contrary, the net AUC for prolactin in response to TRH stimulation was significantly higher than in controls (P = 0.001). In post-menopausal patients, basal E-2, FSH, LH and prolactin levels were not significantly different between women with SSc and controls. However, after TRH stimulation, peak levels and net AUC for prolactin were not significantly higher in patients than those in controls. No significant correlations were found between basal and stimulated FSH, LH and prolactin levels and the severity of involvement of various organ systems. Multiple regression analysis showed that basal and stimulated prolactin concentrations were associated with skin sclerosis and peripheral vascular and lung involvement. Conclusion. Our results suggest that subclinical primary hypogonadism can occur in SSc patients. They also confirm an alteration in the mechanism forprolactin secretion and release, which may not only contribute to further disturbance of the reproductive axis but may also have an influence on the disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:34:30