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Titolo:
Cerebrospinal fluid biogenic amine metabolites, plasma-rich platelet serotonin and [H-3]imipramine reuptake in the primary fibromyalgia syndrome
Autore:
Legangneux, E; Mora, JJ; Spreux-Varoquaux, O; Thorin, I; Herrou, M; Alvado, G; Gomeni, C;
Indirizzi:
Univ Caen, Dept Psychiat, F-14032 Caen, France Univ Caen Caen France F-14032 Caen, Dept Psychiat, F-14032 Caen, France Hosp Bayeux, Dept Rheumatol, Bayeux, France Hosp Bayeux Bayeux FranceHosp Bayeux, Dept Rheumatol, Bayeux, France Hosp Versailles, Dept Pharmacol, Versailles, France Hosp Versailles Versailles France s, Dept Pharmacol, Versailles, France Univ Caen, Dept Pharmacol, F-14032 Caen, France Univ Caen Caen France F-14032 Caen, Dept Pharmacol, F-14032 Caen, France Hosp Bayeux, Dept Surg, Bayeux, France Hosp Bayeux Bayeux FranceHosp Bayeux, Dept Surg, Bayeux, France Biotrial, Rennes, France Biotrial Rennes FranceBiotrial, Rennes, France
Titolo Testata:
RHEUMATOLOGY
fascicolo: 3, volume: 40, anno: 2001,
pagine: 290 - 296
SICI:
1462-0324(200103)40:3<290:CFBAMP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMIPRAMINE BINDING-SITES; SUBSTANCE-P; FIBROSITIS SYNDROME; MONOAMINE METABOLITES; RHEUMATOID-ARTHRITIS; DEPRESSED-PATIENTS; CHRONIC PAIN; DISORDER; SERUM; INDIVIDUALS;
Keywords:
primary fibromyalgia syndrome; matched controls; serotonin; norepinephrine; dopamine; cerebrospinal fluid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Legangneux, E Sanofi Synthelabo, 1 Av Pierre Brossolette, F-91380 Chilly Mazarin, France Sanofi Synthelabo 1 Av Pierre Brossolette Chilly Mazarin France F-91380
Citazione:
E. Legangneux et al., "Cerebrospinal fluid biogenic amine metabolites, plasma-rich platelet serotonin and [H-3]imipramine reuptake in the primary fibromyalgia syndrome", RHEUMATOLOG, 40(3), 2001, pp. 290-296

Abstract

Background. Primary fibromyalgia syndrome (PFS) is a chronic disorder commonly seen in rheumatological practice. The pathophysiological disturbances of this syndrome, which was defined by the American College of Rheumatologyin 1990, are poorly understood. This study evaluated, in 30 patients, the hypothesis that PFS is a pain modulation disorder induced by deregulation of serotonin metabolism. Objectives. To compare platelet [H-3]imipramine binding sites and serotonin (5-HT) levels in plasma-rich platelets (PRP) of PFS patients with those of matched healthy controls and to compare the levels of biogenic amine metabolites in the cerebrospinal fluid (CSF) of PFS patients with those of matched controls. Methods. Platelet [H-3]imipramine binding sites were defined by two criteria, B-max for their density and K-d for their affinity. PRP 5-HT and CSF metabolites of 5-HT (5-hydroxyindoleacetic acid, 5-HIAA), norepinephrine (3-methoxy, 4-hydroxy phenylglycol, MHPG) and dopamine (homovanillic acid, HVA)were assayed by reversed-phase high-performance liquid chromatography withcoulometric detection. Results. [H-3]Imipramine platelet binding was similar (P = 0.43 for B-max and P = 0.30 for K-d) ill PFS patients (B-max = 901 +/- 83 fmol/mg protein,K-d = 0.682 +/- 0.046) and in matched controls (B-max = 1017 +/- 119 fmol/mg protein, K-d = 0.606 +/- 0.056). PRP 5-HT was significantly higher (P = 0.0009) in PFS patients (955 +/- 101 ng/10(9) platelets) than in controls (633 +/- 50 ng/10(9) platelets). When adjusted for age, the levels of all CSF metabolites were lower in PFS patients. The CSF metabolite of norepinephrine (MHPG) was lower (P = 0.003) in PFS patients (8.33 +/- 0.33 ng/ml) thanin matched controls (9.89 +/- 0.31 ng;ml) and 5-HIAA was lower (P = 0.042)in PFS female patients (22.34 +/- 1.78 ng/ml) than in matched controls (25.75 +/- 1.75 ng/ml). For HVA in females, the difference between PFS patients (36.32 +/- 3.20 ng/ml) and matched controls (38.32 +/- 2.90 ng/ml) approached statistical significance (P = 0.054). Conclusion. Changes in metabolites of CSF biogenic amines appear to be partially correlated to age but remained diagnosis-dependent. High levels of PRP 5-HT in PFS patients were associated with low CSF 5-HIAA levels in female patients but were not accompanied by any change in serotonergic uptake asassessed by platelet [H-3]imipramine binding sites. These findings do not allow us to confirm that serotonin metabolism is deregulated in PFS patients.

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Documento generato il 23/10/20 alle ore 14:10:54