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Titolo:
The effect of ribavirin to treat previously healthy infants admitted with acute bronchiolitis on acute and chronic respiratory morbidity
Autore:
Everard, ML; Swarbrick, A; Rigby, AS; Milner, AD;
Indirizzi:
Childrens Hosp, Div Child Hlth, Sheffield S10 2TH, S Yorkshire, England Childrens Hosp Sheffield S Yorkshire England S10 2TH S Yorkshire, England Queens Med Ctr, Paediat Resp Unit, Nottingham NG7 2UH, England Queens Med Ctr Nottingham England NG7 2UH t, Nottingham NG7 2UH, England
Titolo Testata:
RESPIRATORY MEDICINE
fascicolo: 4, volume: 95, anno: 2001,
pagine: 275 - 280
SICI:
0954-6111(200104)95:4<275:TEORTT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNCYTIAL VIRUS-INFECTION; AIRWAY RESPONSIVENESS; TRACT INFECTION; WHEEZY INFANTS; FOLLOW-UP; ASTHMA; EPIDEMIOLOGY; MANAGEMENT; RESPONSES; CHILDREN;
Keywords:
respiratory syncytial virus; acute bronchiolitis; ribavirin; respiratory morbidity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Everard, ML Childrens Hosp, Paediat Resp Unit, Western Bank, Sheffield S102TH, S Yorkshire, England Childrens Hosp Western Bank Sheffield S Yorkshire England S10 2TH
Citazione:
M.L. Everard et al., "The effect of ribavirin to treat previously healthy infants admitted with acute bronchiolitis on acute and chronic respiratory morbidity", RESP MED, 95(4), 2001, pp. 275-280

Abstract

The role of ribavirin in the treatment or acute bronchiolitis is controversial. It has been suggested that the use of ribavirin mag. be of benefit during the acute illness and may reduce subsequent recurrent respiratory morbidity. This randomized, double-blind, placebo-controlled study was designedto determine whether ribavirin administered during the acute illness wouldhave an influence on respiratory morbidity during both the acute illness and during the following year. Bronchial reactivity 6 months after the acuteillness was also assessed. Forty previously well infants with moderately severe acute bronchiolitis M ere recruited during three winter epidemics. Subjects received study medication for 18 h a day. Management was otherwise unaltered. Subjects were evaluated daily by the investigator and subsequently assessed at 6 weeks, 6 months and year following the acute illness. Assessment of bronchial hyper-responsiveness was assessed at 6 months of age using total body plethysmography and an established ultra-sonically nebulized distilled water challenge. A total of 40 patients (21 ribavirin, 19 placebo) were entered into the study. The two groups did not differ with respect to age, gender or clinical severity on entry to the trial. No significant differences were identified in the rate of clinical improvement over the first 24 h. the time to discharge, bronchial responsiveness at 6 months of age, frequency of significant respirator?; symptoms over the first year of life and the frequency of prescribed bronchodilators and inhaled steroids during the year of follow-up. This study was unable to demonstrate any clinical benefit from the use of ribavirin in the acute illness or during subsequent follow-up for 1 year. (C)2001 HARCOURt PuBLISHERS LTD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 17:47:22