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Titolo:
alpha(2) Adrenergic receptors and the central control of breathing in the cane toad, Bufo marinus
Autore:
Rives, JE; Bernard, DG;
Indirizzi:
Univ Texas, Dept Biol, Arlington, TX 76019 USA Univ Texas Arlington TX USA 76019 xas, Dept Biol, Arlington, TX 76019 USA
Titolo Testata:
RESPIRATION PHYSIOLOGY
fascicolo: 3, volume: 125, anno: 2001,
pagine: 213 - 223
SICI:
0034-5687(200104)125:3<213:AARATC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR ACTIONS; CONSCIOUS CATS; CLONIDINE; STIMULATION; NEURONS; CATECHOLAMINES; RESPONSES; DRUGS; AWAKE; GOATS;
Keywords:
amphibians, cane toad, Bufo marinus; control of breathing, central, adrenergic; pharmacological agents, clonidine, yohimbine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Bernard, DG Univ Texas, Dept Biol, 501 Nedderman Dr,Box 19498, Arlington, TX 76019 USA Univ Texas 501 Nedderman Dr,Box 19498 Arlington TX USA 76019 A
Citazione:
J.E. Rives e D.G. Bernard, "alpha(2) Adrenergic receptors and the central control of breathing in the cane toad, Bufo marinus", RESP PHYSL, 125(3), 2001, pp. 213-223

Abstract

The effect of adrenergic agents on the central control of breathing in thecane toad, Bufo marinus. was tested by applying adrenergic agents to the ventral medullary surface of decerebrate adult toads. Toads were unidirectionally ventilated while recording lung, buccal, and artery blood pressures (BPI), as well as heart rate (HR). Following a control period, filter paper pledgets soaked in the appropriate solution (epinephrine - 0.023, 0.05, 0.10, and 0.23 mM; norepinephrine - 0.002, 0.016, 0.032, and 0.16 mM; clonidine - 0.00375, 0.0375, and 0.375 mM: or yohimbine - 0.43) mM) were placed bilaterally on the ventral medullary surface. Epinephrine significantly increased the number of breaths (26%), lung amplitude (9%). and episode duration (21%), but had no effect on BP or HR. The alpha (2)-agonist. clonidine, significantly increased respiratory activity at moderate doses (0.0375 mM) anddecreased activity at high doses (0.375 mM), however, it failed to elicit significant changes in BP or HR. Pretreatment with the alpha (2)-adrenoceptor antagonist, yohimbine (0.43 mM), blocked the clonidine induced changes in respiratory activity. Yohimbine had no effect on cardiorespiratory parameters. Norepinephrine had no effect on either cardiovascular or respiratory variables. Thus, it appears that an alpha (2) adrenergic mechanism is involved in the central control of respiration in this lower vertebrate. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:24:33