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Titolo:
Dopamine, but not glutamate, receptor blockade in the basolateral amygdalaattenuates conditioned reward in a rat model of relapse to cocaine-seekingbehavior
Autore:
See, RE; Kruzich, PJ; Grimm, JW;
Indirizzi:
Med Univ S Carolina, Dept Physiol & Neurosci, Charleston, SC 29425 USA MedUniv S Carolina Charleston SC USA 29425 sci, Charleston, SC 29425 USA Natl Inst Drug Abuse, Intramural Res Program, Baltimore, MD 21224 USA NatlInst Drug Abuse Baltimore MD USA 21224 gram, Baltimore, MD 21224 USA
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 154, anno: 2001,
pagine: 301 - 310
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; SELF-ADMINISTERED COCAINE; NUCLEUS-ACCUMBENS; IN-VIVO; AUTORADIOGRAPHIC DISTRIBUTION; ANTAGONIST SCH-23390; EXCITOTOXIC LESIONS; SYNAPTIC PLASTICITY; PLACE PREFERENCE; HUMAN-BRAIN;
Keywords:
basolateral amygdala; cocaine; dopamine; relapse; reward; self-administration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: See, RE Med Univ S Carolina, Dept Physiol & Neurosci, 173 Ashley Ave, Charleston, SC 29425 USA Med Univ S Carolina 173 Ashley Ave Charleston SC USA 29425 425 USA
Citazione:
R.E. See et al., "Dopamine, but not glutamate, receptor blockade in the basolateral amygdalaattenuates conditioned reward in a rat model of relapse to cocaine-seekingbehavior", PSYCHOPHAR, 154(3), 2001, pp. 301-310

Abstract

Rationale: Following chronic cocaine self-administration and extinction, lesions of the basolateral amygdala (BLA) will significantly attenuate responding for secondary reward (tone + light previously paired with cocaine), without disrupting lever responding for primary reward. However, the specific neurotransmitters involved in conditioned reinstatement remain to be determined. Objective: In the present study, we examined possible receptor substrates of amygdalar regulation of conditioned reinstatement after chronic cocaine self-administration. Methods: Rats were allowed 2 weeks of 3-h dailysessions of cocaine self-administration along a fixed ratio (FR) 1 schedule. After 1 week of daily 3-h extinction sessions in which no programmed consequences occurred, selective antagonists of glutamate or dopamine (DA) receptors were bilaterally infused at single doses into the BLA prior to testing for a cocaine-conditioned reward (tone + light). Following three more days of extinction trials, receptor antagonist effects on reinstatement of cocaine self-administration in the absence of the conditioned stimulus were determined. Results: Infusion of an NMDA receptor antagonist (AP-5, 1.97 mug/side), a kainate/alpha -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid(AMPA) receptor antagonist (CNQX, 0.83 mug/side), or both drugs together had no significant effects on conditioned reward or reinstatement of cocaineself-administration. In contrast, infusion of a DA D, receptor antagonist (SCH-23390, 2 mug/side) or a combination of SCH-23390 and a DA D-2/D-3 receptor antagonist (raclopride, 5 mug/side) significantly reduced responding for conditioned reward, but did not affect cocaine self-administration. Raclopride alone was without effect on either test day. Conclusions: These results sugdgest that conditioned reinstatement of drug-seeking behavior is dependent on amygdalar D-1 receptors.

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Documento generato il 08/04/20 alle ore 12:07:17