Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Methadone patients exhibit increased startle and cortisol response after intravenous yohimbine
Autore:
Stine, SM; Grillon, CG; Morgan, CA; Kosten, TR; Charney, DS; Krystal, JH;
Indirizzi:
Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Detroit, MI 48092 USA Wayne State Univ Detroit MI USA 48092 hav Neurosci, Detroit, MI 48092 USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06519 USA Yale Univ New Haven CT USA 06519 , Dept Psychiat, New Haven, CT 06519 USA VA Connecticut Healthcare Syst, W Haven, CT 06516 USA VA Connecticut Healthcare Syst W Haven CT USA 06516 W Haven, CT 06516 USA
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 154, anno: 2001,
pagine: 274 - 281
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTTRAUMATIC-STRESS-DISORDER; ACOUSTIC STARTLE; LOCUS-COERULEUS; NORADRENERGIC FUNCTION; SENSORIMOTOR REACTIVITY; CELLULAR MECHANISMS; WITHDRAWAL SYMPTOMS; DEPRESSED-PATIENTS; OPIATE-WITHDRAWAL; HEALTHY-SUBJECTS;
Keywords:
methadone; noradrenergic; opioid; startle; yohimbine; hormone; HPA axis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Stine, SM Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, 2761 E Jefferson Ave, Detroit, MI 48092 USA Wayne State Univ 2761 E Jefferson Ave Detroit MI USA 48092 2 USA
Citazione:
S.M. Stine et al., "Methadone patients exhibit increased startle and cortisol response after intravenous yohimbine", PSYCHOPHAR, 154(3), 2001, pp. 274-281

Abstract

dBrain noradrenergic systems have been shown to be altered in opioid dependence and to mediate aspects of opioid withdrawal. Pre-clinical and clinical studies by others have shown that yohimbine, which increases noradrenergic activity, also increases both baseline and fear enhancement of the magnitude of the acoustic startle response (ASR). In a separate report from this experiment, it was shown that yohimbine produced opioid withdrawal-like symptoms, including anxiety, in clinically stable methadone-maintained patients and also produced elevations in the norepinepherine (NE) metabolite, 3-methoxy-4 hydroxyphenethyleneglycol (MHPG), and cortisol serum levels. The current study reports the effects of intravenous yohimbine hydrochloride. 0.4mg/kg versus saline (double-blind), on ASR magnitude, plasma MHPG, and cortisol levels in eight methadone-maintained patients and 13 healthy subjectsin a double-blind fashion. Yohimbine increased startle magnitude in both groups. There was no basal (placebo day) difference between the startle response of the two groups, but methadone patients had a larger startle magnitude increase in response to yohimbine than healthy controls. Methadone-maintained patients had lower baseline plasma levels of MHPG and similar baseline plasma cortisol levels compared with normal subjects. Yohimbine caused significant elevation in cortisol and MHPG in both groups. Methadone-maintained subjects had higher elevations in cortisol levels and MHPG (methadone main effect) levels in response to yohimbine. However, when MHPG levels were corrected for baseline differences by analysis of covariance (ANCOVA), the yohimbine effect, but not the methadone effect remained statistically significant. These results are consistent with the previous report and support the hypothesis that abnormalities of the hypothalamic-pituitary-adrenal (HPA) axis and of noradrenergic mechanisms of stress response persist in opioid-agonist maintenance. The ASR effect extends the previous report and provides an additional objective measure for perturbation of noradrenergic and stress responses in these patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:55:22