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Titolo:
Effects of nitric oxide synthase inhibitors on the discriminative stimuluseffects of cocaine in rats
Autore:
Collins, SL; Edwards, MA; Kantak, KM;
Indirizzi:
Boston Univ, Dept Psychol, Lab Behav Neurosci, Boston, MA 02215 USA BostonUniv Boston MA USA 02215 Lab Behav Neurosci, Boston, MA 02215 USA
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 154, anno: 2001,
pagine: 261 - 273
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; D-ASPARTATE ANTAGONISTS; ARGININE METHYL-ESTER; 7-NITRO INDAZOLE; BEHAVIORAL SENSITIZATION; NUCLEUS-ACCUMBENS; STRIATAL DOPAMINE; SQUIRREL-MONKEYS; NO PATHWAY; BRAIN;
Keywords:
cocaine; drug discrimination; haloperidol; L-NAME; 7-NI; nitric oxide synthase inhibitor; SCH 23390;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Kantak, KM Boston Univ, Dept Psychol, Lab Behav Neurosci, 64 Cummington St, Boston, MA 02215 USA Boston Univ 64 Cummington St Boston MA USA 02215 , MA 02215 USA
Citazione:
S.L. Collins et al., "Effects of nitric oxide synthase inhibitors on the discriminative stimuluseffects of cocaine in rats", PSYCHOPHAR, 154(3), 2001, pp. 261-273

Abstract

Rationale: Nitric oxide synthase (NOS) inhibitors may modulate the discriminative stimulus effects of cocaine because they alter dopamine (DA) release. Objectives: The effects of the NOS inhibitors N(G)nitro-L-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI) were examined in experiments designed to better understand the mechanisms that may underlie the interactions between NOS inhibitors and cocaine. Methods: Rats were trained to discriminate 10 mg/kg cocaine from saline, and then substitution and pretreatmenttests with L-NAME and 7-NI were conducted. To determine if the combined effects of NOS inhibitors and cocaine might be related to DA mechanisms and/or to N-methyl-D-aspartate (NMDA) receptor mechanisms, substitution tests with other indirect DA agonists and NMDA antagonists were carried out in the presence and absence of L-NAME. In addition, the roles of the D-1 and D-2 families of DA receptors in mediating the cocaine-altering effects of L-NAMEand 7-NI were examined in antagonism tests using SCH 23390 and haloperidol, respectively. Results: The results demonstrated that neither NOS inhibitor alone substituted for the 10 mg/kg cocaine training dose, but when given as a pretreatment, 100 mg/kg L-NAME as well as 10 mg/kg 7-NI enhanced the discriminative stimulus and rate-decreasing effects of cocaine. L-NAME pretreatment also enhanced the potency of (+)-amphetamine and GBR 12909, but notMK-801, phencyclidine, or NPC 17742, for producing discriminative stimulusand rate-decreasing effects in substitution tests. Further testing showed that the cocaine-enhancing effects of L-NAME and 7-NI were attenuated by doses of haloperidol and SCH 23390 that minimally altered the effects of cocaine alone. Conclusions: These findings suggest that L-NAME and 7-NI may increase the potency of cocaine and other indirect DA agonists through a central mechanism whereby DA neurotransmission is directly enhanced by NOS inhibition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:32:53