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Titolo:
Effects of procyclidine on prepulse inhibition of the acoustic startle response in healthy human volunteers
Autore:
Kumari, V; Zachariah, E; Galea, A; Mehrotra, R; Taylor, D; Sharma, T;
Indirizzi:
Inst Psychiat, Sect Cognit Psychopharmacol, Div Psychol Med, London SE5 8AF, England Inst Psychiat London England SE5 8AF sychol Med, London SE5 8AF, England Inst Psychiat, Dept Psychol, London SE5 8AF, England Inst Psychiat London England SE5 8AF pt Psychol, London SE5 8AF, England Maudsley Hosp, London SE5 8AF, England Maudsley Hosp London England SE5 8AF dsley Hosp, London SE5 8AF, England
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 154, anno: 2001,
pagine: 221 - 229
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFORMATION-PROCESSING DEFICITS; SCHIZOPHRENIC-PATIENTS; ANTICHOLINERGIC MEDICATION; CHOLINERGIC MODULATION; ANIMAL-MODEL; REFLEX; RAT; NICOTINE; DRUGS; SYMPTOMS;
Keywords:
acoustic startle response; prepulse inhibition; anticholinergic drug; antipsychotic drug; procyclidine; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Kumari, V Inst Psychiat, Sect Cognit Psychopharmacol, Div Psychol Med, De Crespigny Pk, London SE5 8AF, England Inst Psychiat De Crespigny Pk LondonEngland SE5 8AF F, England
Citazione:
V. Kumari et al., "Effects of procyclidine on prepulse inhibition of the acoustic startle response in healthy human volunteers", PSYCHOPHAR, 154(3), 2001, pp. 221-229

Abstract

Rationale: Prepulse inhibition (PPI) of the startle response refers to an attenuation in response to a strong stimulus (pulse) if this is preceded shortly by a weak non-startling stimulus (prepulse). Patients with schizophrenia have repeatedly been found to show reduced PPI when compared to healthypeople. Anticholinergic drugs are often used to control extrapyramidal symptoms induced by antipsychotic medication in schizophrenic patients. Antipsychotic medication, in particular with atypical drugs, has been shown to improve a range of cognitive functions and normalize PPI deficits in schizophrenia, whereas anticholinergic drugs disrupt cognitive functions in both normal and schizophrenic populations and also impair PPI in experimental animals. No previous study has investigated the effects of anticholinergic drugs on human PPI. Objectives: This study determined the effects of procyclidine, an anticholinergic drug, on PPI in healthy male volunteers. employing adouble-blind placebo-controlled cross-over design. Methods: Subjects underwent testing for PPI on two occasions: once after the oral administration of a placebo and once after the oral administration of procyclidine in two separate experiments. Experiment 1 examined the effects of 10 mg procyclidine, whereas experiment 2 examined the effects of 15 mg procyclidine. Results: Procyclidine at a 10 mg dose, as compared to placebo, had no effect on PPI, but caused impairments at a 15 mg dose. In both experiments, procyclidine reduced response amplitude over the pulse-alone trials and heart rate 1-2h post-administration. Conclusions: PPI of the human acoustic startle response is modulated by procyclidine. The use of anticholinergics needs to be considered in PPI studies in schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 08:59:02