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Titolo:
Evolution of pathogen virulence: the role of variation in host phenotype
Autore:
Pfennig, KS;
Indirizzi:
Univ Bristol, Sch Biol Sci, Bristol BS8 1UG, Avon, England Univ Bristol Bristol Avon England BS8 1UG Bristol BS8 1UG, Avon, England
Titolo Testata:
PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
fascicolo: 1468, volume: 268, anno: 2001,
pagine: 755 - 760
SICI:
0962-8452(20010407)268:1468<755:EOPVTR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALARIA PLASMODIUM-CHABAUDI; PARASITE VIRULENCE; MATE CHOICE; POPULATION-STRUCTURE; CYTOKINE PRODUCTION; TOXOPLASMA-GONDII; LOCAL ADAPTATION; CLONE INFECTIONS; KIN SELECTION; IMMUNE-SYSTEM;
Keywords:
pathogen; virulence; alternative strategies; polymorphism; polyphenism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Pfennig, KS Univ Texas, Sect Integrat Biol, Austin, TX 78712 USA Univ Texas Austin TX USA 78712 rat Biol, Austin, TX 78712 USA
Citazione:
K.S. Pfennig, "Evolution of pathogen virulence: the role of variation in host phenotype", P ROY SOC B, 268(1468), 2001, pp. 755-760

Abstract

Selection on pathogens tends to favour the evolution of growth and reproductive rates and a concomitant level of virulence (damage done to the host) that maximizes pathogen fitness. Yet, because hosts often pose varying selective environments to pathogens, one level of virulence may not be appropriate for all host types. Indeed, if a level of virulence confers high fitness to the pathogen in one host phenotype but low fitness in another host phenotype, alternative virulence strategies may be maintained in the pathogen population. Such strategies can occur either as polymorphism, where different strains of pathogen evolve specialized virulence strategies in differenthost phenotypes or as polyphenism, where pathogens facultatively express alternative virulence strategies depending on host phenotype. Polymorphism potentially leads to specialist pathogens capable of infecting a limited range of host phenotypes, whereas polyphenism potentially leads to generalist pathogens capable of infecting a wider range of hosts. Evaluating how variation among hosts affects virulence evolution can provide insight into pathogen diversity and is critical in determining how host-pathogen interactionsaffect the phenotypic evolution of both hosts and pathogens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:47:17