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Titolo:
Diacylglycerol kinase epsilon regulates seizure susceptibility and long-term potentiation through arachidonoylinositol lipid signaling
Autore:
de Turco, EBR; Tang, W; Topham, MK; Sakane, F; Marcheselli, VL; Chen, C; Taketomi, A; Prescott, SM; Bazan, NC;
Indirizzi:
Univ Utah, Huntsman Canc Inst, Salt Lake City, UT 84112 USA Univ Utah Salt Lake City UT USA 84112 Inst, Salt Lake City, UT 84112 USA Louisiana State Univ, Hlth Sci Ctr, Neurosci Ctr Excellence, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 , New Orleans, LA 70112 USA Louisiana State Univ, Hlth Sci Ctr, Dept Ophthalmol, New Orleans, LA 70112USA Louisiana State Univ New Orleans LA USA 70112 l, New Orleans, LA 70112USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 8, volume: 98, anno: 2001,
pagine: 4740 - 4745
SICI:
0027-8424(20010410)98:8<4740:DKERSS>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE RECEPTORS; PLATELET-ACTIVATING-FACTOR; MGLUR1 MUTANT MICE; TRANSCRIPTIONAL ACTIVATION; ELECTROCONVULSIVE SHOCK; SYNAPTIC TRANSMISSION; MEMBRANE-FUNCTION; ARACHIDONIC-ACID; MESSENGER; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Prescott, SM Univ Utah, Huntsman Canc Inst, Salt Lake City, UT 84112 USA Univ Utah Salt Lake City UT USA 84112 ake City, UT 84112 USA
Citazione:
E.B.R. de Turco et al., "Diacylglycerol kinase epsilon regulates seizure susceptibility and long-term potentiation through arachidonoylinositol lipid signaling", P NAS US, 98(8), 2001, pp. 4740-4745

Abstract

Arachidonoyldiacylglycerol (20:4-DAG) is a second messenger derived from phosphatidylinositol 4,5-bisphosphate and generated by stimulation of glutamate metabotropic receptors linked to C proteins and activation of phospholipase C. 20:4-DAG signaling is terminated by its phosphorylation to phosphatidic acid, catalyzed by diacylglycerol kinase (DGK). We have cloned the murine DGK epsilon gene that showed, when expressed in COS-7 cells, selectivity for 20:4-DAG. The significance of DGKe in synaptic function was investigated in mice with targeted disruption of the DGK epsilon. DCK epsilon (-/-) mice showed a higher resistance to eletroconvulsive shock with shorter tonic seizures and faster recovery than DGK epsilon (+/+) mice. The phosphatidylinositol 4,5-bisphosphate-signaling pathway in cerebral cortex was greatlyaffected, leading to lower accumulation of 20:4-DAG and free 20:4. Also, long-term potentiation was attenuated in perforant path-dentate granular cell synapses. We propose that DGK epsilon contributes to modulate neuronal signaling pathways linked to synaptic activity, neuronal plasticity, and epileptogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:31:13