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Titolo:
Epstein-Barr virus latent-infection membrane proteins are palmitoylated and raft-associated: Protein 1 binds to the cytoskeleton through TNF receptorcytoplasmic factors
Autore:
Higuchi, M; Izumi, KM; Kieff, E;
Indirizzi:
Brigham & Womens Hosp, Channing Lab, Dept Med, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 Dept Med, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 robiol & Mol Genet, Boston, MA 02115 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 8, volume: 98, anno: 2001,
pagine: 4675 - 4680
SICI:
0027-8424(20010410)98:8<4675:EVLMPA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; LYMPHOCYTE GROWTH TRANSFORMATION; GLYCOSPHINGOLIPID-RICH COMPLEXES; MEMBRANE-PROTEIN-1 ENGAGES; TRANSMEMBRANE DOMAINS; SIGNAL-TRANSDUCTION; TYROSINE KINASES; AMINO-TERMINUS; LIPID RAFTS; JNK PATHWAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Kieff, E Brigham & Womens Hosp, Channing Lab, Dept Med, 181 Longwood Ave, Boston, MA 02115 USA Brigham & Womens Hosp 181 Longwood Ave Boston MA USA 02115 15 USA
Citazione:
M. Higuchi et al., "Epstein-Barr virus latent-infection membrane proteins are palmitoylated and raft-associated: Protein 1 binds to the cytoskeleton through TNF receptorcytoplasmic factors", P NAS US, 98(8), 2001, pp. 4675-4680

Abstract

Epstein-Barr virus encodes integral membrane proteins LMP1 and LMP2A in transformed lymphoblastoid cell lines. We now find that LMP1 associates with the cell cytoskeleton through a tumor necrosis factor receptor-associated factor-interacting domain, most likely mediated by tumor necrosis factor receptor-associated factor 3. LMP1 is palmitoylated, and the transmembrane domains associate with lipid rafts. Mutation of LMP1 cysteine-78 abrogates palmitoylation but does not affect raft association or NF-kappaB or c-Jun N-terminal kinase activation. LMP2A also associates with rafts and is palmitoylated but does not associate with the cell cytoskeleton. The associations ofLMP1 and LMP2A with rafts and of LMP1 with the cell cytoskeleton are likely to effect interactions with cell proteins involved in shape, motility, signal transduction, growth, and survival.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:25:32