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Titolo:
Attenuation of morphine dependence and withdrawal by glycine(B) site antagonists in rats
Autore:
Kotlinska, J;
Indirizzi:
Med Univ Sch, Dept Pharmacodynam, PL-20081 Lublin, Poland Med Univ Sch Lublin Poland PL-20081 armacodynam, PL-20081 Lublin, Poland
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 1, volume: 68, anno: 2001,
pagine: 157 - 161
SICI:
0091-3057(200101)68:1<157:AOMDAW>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRECIPITATED OPIOID WITHDRAWAL; ASPARTATE RECEPTOR ANTAGONIST; NMDA RECEPTOR; PHYSICAL-DEPENDENCE; OPIATE WITHDRAWAL; LOCUS-COERULEUS; GLUTAMATE; L-701,324; INHIBITION; EXPRESSION;
Keywords:
morphine dependence and withdrawal; MK801; glycine(B) site antagonists; L-701,324; 5,7-DCKA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Kotlinska, J Med Univ Sch, Dept Pharmacodynam, Staszica 4, PL-20081 Lublin, Poland Med Univ Sch Staszica 4 Lublin Poland PL-20081 ublin, Poland
Citazione:
J. Kotlinska, "Attenuation of morphine dependence and withdrawal by glycine(B) site antagonists in rats", PHARM BIO B, 68(1), 2001, pp. 157-161

Abstract

Numerous data indicate that noncompetitive and competitive N-methyl-D-aspartate (NMDA) receptor antagonists inhibit the development of physical dependence on opioids when these substances are administered together, and NMDA receptor antagonists are used at lower range of doses. Higher doses of these antagonists can enhance some opioid-induced effects. The present study extends these findings to the effects of NMDA/glycine (glycine(B)) site antagonists. Wistar rats were rendered dependent on morphine by implantation of morphine pellets. Both of the glycine(B) site antagonists used, 7-chloro-4-hydroxy-3-(3-phenoxy)-phenyl-2(H)-quinolone (L-701,3 24; 2.5 and 5.0 mg/kg)and 5,7-dichlorokynurenic acid (5,7-DCKA; 25, 50, and 100 mg/kg), suppressed the expression of morphine withdrawal syndrome estimated as wet dog shakes. Furthermore, L-701,324 (2.5 and 5 mg/kg), given twice a day during the development of morphine dependence, attenuated the development of morphine dependence, and the results were comparable to those obtained after administration of noncompetitive NMDA receptor antagonist - MK801 (0.1 mg/kg). Ourdata suggest that glycine(B) site antagonists may attenuate wet dog shakes(withdrawal) and the development of dependence, both being induced by chronic morphine administration in rats. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 04:03:10