Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Salmon calcitonin potentiates the analgesia induced by antidepressants
Autore:
Ormazabal, MJ; Goicoechea, C; Sanchez, E; Martin, MI;
Indirizzi:
Univ Complutense Madrid, Dept Farmacol, Fac Med, E-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain E-28040 Med, E-28040 Madrid, Spain
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 1, volume: 68, anno: 2001,
pagine: 125 - 133
SICI:
0091-3057(200101)68:1<125:SCPTAI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHANTOM LIMB PAIN; CENTRAL SEROTONERGIC PATHWAYS; REFLEX SYMPATHETIC DYSTROPHY; FORCED SWIMMING TEST; ANTINOCICEPTIVE ACTIVITY; MORPHINE ANALGESIA; RAT; MICE; AMITRIPTYLINE; DRUGS;
Keywords:
nortriptyline; amitriptyline; paroxetine; calcitonin; analgesia; mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Martin, MI Univ Complutense Madrid, Dept Farmacol, Fac Med, Avda Complutense S-N,Ciudad Univ, E-28040 Madrid, Spain Univ Complutense Madrid Avda Complutense S-N,Ciudad Univ Madrid Spain E-28040
Citazione:
M.J. Ormazabal et al., "Salmon calcitonin potentiates the analgesia induced by antidepressants", PHARM BIO B, 68(1), 2001, pp. 125-133

Abstract

Antidepressants are used in the treatment of a variety of pain syndromes. Most of them act by blocking noradrenaline (NA) and serotonin (5-HT) reuptake. It is also well known that the serotonergic system is also involved in calcitonin (CT) analgesia. Taking these two evidences into account, the modification of the analgesic effect of nortriptyline, amitripcyline, and paroxetine in the presence of salmon CT (s-CT) was examined in mice. The forced-swimming test was carried out in order to choose doses of each drug that did not induce an antidepressant effect under our experimental conditions (nortriptyline: 0.2-5 mg/kg ip, amitriptyline: 2.5-20 mg/kg ip, and paroxetine: 5-30 mg/kg ip). The analgesic effect of each antidepressant was then evaluated using the acetic acid test. At the doses tested, the antidepressantsinduced a dose-dependent analgesic effect. When mice were pre-treated witha subanalgesic dose of s-CT (2.5 IU/kg), the analgesic effect of amitriptyline and paroxetine was significantly increased though no modification was found for nortriptyline. In summary, s-CT was able to increase the analgesic effect of the antidepressant drugs that reduce the uptake of 5-HT, suggesting that the joint administration of antidepressants and CT may be an interesting alternative in pain management. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 23:51:59