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Titolo:
The effect of the NMDA receptor blocker, dextromethorphan, on cribbing in horses
Autore:
Rendon, RA; Shuster, L; Dodman, NH;
Indirizzi:
Tufts Univ, Sch Vet Med, Dept Clin Sci, N Grafton, MA 01536 USA Tufts Univ N Grafton MA USA 01536 Dept Clin Sci, N Grafton, MA 01536 USA Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USATufts Univ Boston MA USA 02111 col & Expt Therapeut, Boston, MA 02111 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 1, volume: 68, anno: 2001,
pagine: 49 - 51
SICI:
0091-3057(200101)68:1<49:TEOTNR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEREOTYPIC BEHAVIOR;
Keywords:
stereotypic cribbing; horses; NMDA receptor antagonist; dextromethorphan;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Dodman, NH Tufts Univ, Sch Vet Med, Dept Clin Sci, 200 Westboro Rd, N Grafton, MA 01536 USA Tufts Univ 200 Westboro Rd N Grafton MA USA 01536 MA 01536 USA
Citazione:
R.A. Rendon et al., "The effect of the NMDA receptor blocker, dextromethorphan, on cribbing in horses", PHARM BIO B, 68(1), 2001, pp. 49-51

Abstract

Stereotypic cribbing in horses is thought to involve excess dopaminergic activity within the striatum. Various models of stress-induced stereotypies including cribbing in horses postulate that stress stimulates the release of endorphins. triggering the release of striatal dopamine. Dopamine in turnactivates basal ganglia motor programs, reinforcing behavior via a reward mechanism. Furthermore, the release of dopamine by endorphins has been shown to depend on activation of NMDA receptors. In the present study, horses identified as cribbers and volunteered by their owners were treated with theNMDA receptor antagonist dextromethorphan (DM). When DM was administered via jugular injection (1 mg/kg), eight of nine horses responded with reductions in cribbing rate (CR) compared to baseline, and cribbing was suppressedcompletely for a period of time in almost half of the horses tested. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:35:52