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Titolo:
Effects of sweetened ethanol solutions on ethanol self-administration and blood ethanol levels
Autore:
Matthews, DB; Overstreet, DH; Rezvani, AH; Devaud, LL; Morrow, AL;
Indirizzi:
Univ N Carolina, Dept Psychiat, Bowles Ctr Alcohol Studies, Sch Med, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 h Med, Chapel Hill, NC 27599 USA Univ N Carolina, Dept Pharmacol, Bowles Ctr Alcohol Studies, Sch Med, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 h Med, Chapel Hill, NC 27599 USA Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC USA Duke Univ Durham NC USA d Ctr, Dept Psychiat & Behav Sci, Durham, NC USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 1, volume: 68, anno: 2001,
pagine: 13 - 21
SICI:
0091-3057(200101)68:1<13:EOSESO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
RATS DRINKING; ALCOHOL; INITIATION; CONSUMPTION; WITHDRAWAL; SUCROSE/ETHANOL; REINFORCEMENT; DEPENDENCE; METABOLISM; SEIZURES;
Keywords:
ethanol self-administration; sucrose; saccharin; blood ethanol levels; bicuculline seizure thresholds;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Morrow, AL Univ N Carolina, Dept Psychiat, Bowles Ctr Alcohol Studies, SchMed, CB 7178, Chapel Hill, NC 27599 USA Univ N Carolina CB 7178 Chapel Hill NC USA 27599 , NC 27599 USA
Citazione:
D.B. Matthews et al., "Effects of sweetened ethanol solutions on ethanol self-administration and blood ethanol levels", PHARM BIO B, 68(1), 2001, pp. 13-21

Abstract

The enhancement of voluntary self-administration of ethanol by sucrose or saccharin was rested in conjunction with measurements of blood ethanol levels. Adult male rats were given access to both tap water acid one of five solutions: 0.125% saccharin, 10% sucrose, ethanol, saccharin + ethanol, or sucrose + ethanol. The rats receiving the sucrose + ethanol solution drank consistently more ethanol (> 5 g/kg/day) than did the rats receiving the saccharin + ethanol solution (< 3 g/kg/day) or ethanol only (< 2 g/kg/day). Both sweetened solutions produced higher ethanol consumption during these periods than ethanol alone. However, no significant differences in blood ethanol levels were found between the sucrose+ethanol and saccharin+ethanol conditions, when tested at different intervals on Day 44 or Day 45 of ethanol consumption. Following 45 days of consumption, no change in the bicuculline seizure threshold was observed in the ethanol-consuming rats compared to thecontrols. In a separate study using 90 naive rats, rats were gavaged with ethanol (1, 2, or 3 g:kg) containing either 10% sucrose (n = 10 for each dose of ethanol), 0.125% saccharin (n = 10 for each dose of ethanol), or ethanol alone (n = 10 for each dose of ethanol), and blood was collected from the tip of the tail 30, 60, 180, 300, and 540 min later and analyzed for ethanol concentrations. Sucrose significantly decreased the resultant blood ethanol levels at several time points following gavage. These results indicate that sucrose can significantly alter blood ethanol levels and that chronic self-administration of a sweetened ethanol solution for 6 weeks does not produce ethanol dependence. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 11/07/20 alle ore 20:04:39