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Titolo:
Respiratory diseases in the first year of life in children born to HIV-1-infected women
Autore:
Kattan, M; Platzker, A; Mellins, RB; Schluchter, MD; Chen, XC; Peavy, H; Steinbach, S; Wohl, ME; Hiatt, P; Hunter, J; Colin, AA;
Indirizzi:
Mt Sinai Sch Med, Dept Pediat, New York, NY 10029 USA Mt Sinai Sch Med New York NY USA 10029 ept Pediat, New York, NY 10029 USA Univ Calif Los Angeles, Univ So Calif, Dept Pediat, Los Angeles, CA USA Univ Calif Los Angeles Los Angeles CA USA pt Pediat, Los Angeles, CA USA Columbia Univ, Dept Pediat, New York, NY 10027 USA Columbia Univ New YorkNY USA 10027 , Dept Pediat, New York, NY 10027 USA Cleveland Clin Fdn, Dept Biostat & Epidemiol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 demiol, Cleveland, OH 44195 USA NHLBI, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892NHLBI, Bethesda, MD 20892 USA Boston Univ, Sch Med, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 oston Univ, Sch Med, Boston, MA 02118 USA Harvard Univ, Childrens Hosp, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 rens Hosp, Sch Med, Boston, MA 02115 USA Baylor Coll Med, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 ylor Coll Med, Houston, TX 77030 USA
Titolo Testata:
PEDIATRIC PULMONOLOGY
fascicolo: 4, volume: 31, anno: 2001,
pagine: 267 - 276
SICI:
8755-6863(200104)31:4<267:RDITFY>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; PNEUMOCYSTIS-CARINII PNEUMONIA; INFANTS BORN; UNITED-STATES; CYTOMEGALOVIRUS-INFECTION; HIV-INFECTION; PROGRESSION; MORTALITY; TYPE-1; PROPHYLAXIS;
Keywords:
HIV-1 infection; pneumonia; Pneumocystis carinii pneumonia; bronchiolitis; CD4 lymphocytes; infants; radiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Kattan, M Mt Sinai Sch Med, Dept Pediat, Box 1202-B,1 Gustave L Levy Pl, New York, NY 10029 USA Mt Sinai Sch Med Box 1202-B,1 Gustave L Levy Pl New York NY USA 10029
Citazione:
M. Kattan et al., "Respiratory diseases in the first year of life in children born to HIV-1-infected women", PEDIAT PULM, 31(4), 2001, pp. 267-276

Abstract

Our objective was to describe the respiratory complications, clinical findings, and chest radiographic changes in the first year of life in infected and uninfected children born to HIV-1-infected women. We prospectively followed a cohort of 600 infants born to HIV-l-infected women from birth to 12 months in a multicenter study. Of these, 93 infants (15.5%) were HIV-1 infected, 463 were uninfected, and 44 were of unknown status prior to death or loss to follow-up. The cumulative incidence (+/- SE) of an initial pneumonia episode at 12 months was 24.1 +/- 4.7% in HIV-1-infected children compared to 1.4 +/- 0.6% in HIV-1-uninfected children (P < 0.001). The rate of Pneumocystis carinii pneumonia (PCP) was 9.5 per 100 child-years. The HIV-1 RNA load was not higher in the group that developed pneumonia in the first year vs. those who did not. Children who developed lower respiratory tract infections or PCP had increased rates of decline of CD4 cell counts during the first 6 months of life. Lower maternal CD4 cell counts were associated with higher rates ofpneumonia, and upper and lower respiratory tract infections, The rates of upper respiratory tract infection and bronchiolitis/reactive airway diseasein infected children were not significantly different than in uninfected children. At 12 months, significantly more HIV-1-infected than uninfected children had tachypnea and chest radiographs with nodular and reticular densities. There was no relationship between cytomegalo virus infection in the first year of life and radiographic changes or occurrences of pneumonia. In conclusion, despite a low incidence of PCP, rates of pneumonia remain high in HIV-infected children in the first year of life. The incidence of pneumonia in uninfected infants born to HIV-1-infected mothers is low. Chest X-ray abnormalities and tachypnea suggest that subacute disease is present in infected infants. Further follow-up is warranted to determine its nature. <(c)> 2001 Wiley-Liss. Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:35:28