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Titolo:
Morphometric evaluation of nucleolar organizer regions in cervical intraepithelial neoplasia
Autore:
Sakai, YI; Sakai, AT; Isotani, S; Cavaliere, MJ; de Almeida, LV; Calore, EE;
Indirizzi:
Emilio Ribas Infectol Inst, Pathol Sect, BR-01246902 Sao Paulo, Brazil Emilio Ribas Infectol Inst Sao Paulo Brazil BR-01246902 BC Paulo, Brazil Adolfo Lutz Inst, Div Pathol, Sao Paulo, Brazil Adolfo Lutz Inst Sao Paulo Brazil z Inst, Div Pathol, Sao Paulo, Brazil Fed Univ Sao Paulo State, Dept Urol, Sao Paulo, Brazil Fed Univ Sao Paulo State Sao Paulo Brazil Dept Urol, Sao Paulo, Brazil Univ Sao Paulo, Dept Gen Phys, Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil Paulo, Dept Gen Phys, Sao Paulo, Brazil Univ Sao Paulo, Inst Biomed, Dept Pharmacol, Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil omed, Dept Pharmacol, Sao Paulo, Brazil
Titolo Testata:
PATHOLOGY RESEARCH AND PRACTICE
fascicolo: 3, volume: 197, anno: 2001,
pagine: 189 - 192
SICI:
0344-0338(2001)197:3<189:MEONOR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
STAINING METHOD; BREAST-CANCER; SMEARS; NOR;
Keywords:
nucleolar organizer regions; NOR; cervical intraepithelia neoplasia; morphometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Calore, EE Emilio Ribas Infectol Inst, Pathol Sect, Av Dr Arnaldo 165, BR-01246902 Sao Paulo, Brazil Emilio Ribas Infectol Inst Av Dr Arnaldo 165 SaoPaulo Brazil BR-01246902 BC
Citazione:
Y.I. Sakai et al., "Morphometric evaluation of nucleolar organizer regions in cervical intraepithelial neoplasia", PATH RES PR, 197(3), 2001, pp. 189-192

Abstract

The objective of this study was to determine whether some morphometric parameters and two different methods of counting AgNOR dots were correlated with the grade of cervical intraepithelial neoplasia. Thirty uterine cervix biopsies (8 cases of cervicitis, 9 CIN I, CIN II and 6 CIN III) were studied. Two methods were used to count AgNOR dots. The first one consisted of counting the number of epithelial cells with 1, 2, 3, 4, or more dots. The second method, based on a computer analysis system, consisted of counting the total number of dots in 100 cells, without considering the number of dots per cell. Using the same computer analysis system, the following parameters were measured: area, diameter, perimeter, roundness and length of each dot. The following parameters were found to be cell-elated with the grade of intraepithelial neoplasia: 1) number of cells with 1 dot, which decreased with increasing grade of cervical intraepithelial neoplasia; 2) number of cells with 4 dots or more, which increased with increasing grade of cervical intraepithelial neoplasia; 3) total number of dots per 100 cells, which progressively increased with increasing grade of intraepithelial neoplasia. We conclude that counting cells with 4 or more dots is the more trustworthy parameter for distinguishing the grade of cervical intraepithelial neoplasia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/02/20 alle ore 06:17:25