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Titolo:
Encoding of noxious stimulus intensity by putative pain modulating neuronsin the rostral ventromedial medulla and by simultaneously recorded nociceptive neurons in the spinal dorsal horn of rats
Autore:
Hernandez, N; Vanegas, H;
Indirizzi:
Inst Venezolano Invest Cient, Caracas 1020A, Venezuela Inst Venezolano Invest Cient Caracas Venezuela 1020A as 1020A, Venezuela
Titolo Testata:
PAIN
fascicolo: 3, volume: 91, anno: 2001,
pagine: 307 - 315
SICI:
0304-3959(200104)91:3<307:EONSIB>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMATE SPINOTHALAMIC NEURONS; FLICK RELATED ACTIVITY; ON-CELL ACTIVITY; THERMAL-STIMULATION; OFF-CELLS; ANESTHETIZED RAT; GLABROUS SKIN; TRACT CELLS; RESPONSES; WITHDRAWAL;
Keywords:
descending pain control; RVM; nucleus raphe magnus; pain modulating neurons;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Vanegas, H Inst Venezolano Invest Cient, Ctr Biofis Bioquim, 8424 NW 56th St,Suite CCS 00202, Miami, FL 33166 USA Inst Venezolano Invest Cient 8424 NW 56th St,Suite CCS 00202 Miami FL USA 33166
Citazione:
N. Hernandez e H. Vanegas, "Encoding of noxious stimulus intensity by putative pain modulating neuronsin the rostral ventromedial medulla and by simultaneously recorded nociceptive neurons in the spinal dorsal horn of rats", PAIN, 91(3), 2001, pp. 307-315

Abstract

Neurons in the nucleus raphe magnus and adjacent structures of the rostralventromedial medulla (RVM) are involved in the control of nociceptive transmission. In the RVM the so-called on-cells are excited, and the so-called off-cells are inhibited, by noxious stimuli applied almost anywhere on the body surface, thus showing that they receive information from spinal and trigeminal nociceptive neurons. In deeply anesthetized rats, recordings were made from RVM neurons that resembled on- and off-cells (herein called putative on- and off-cells) in order to investigate (1) how they encode the intensity of thermal noxious stimuli (46-56 degreesC) applied to a hindpaw, and(2) how their encoding properties relate to those of simultaneously recorded spinal neurons. In 39 of 98 cases, a graded increase in the stimulus temperature caused a monotonic decrease in the response latency of putative on-cells, putative off-cells and spinal neurons, while the response dischargerate monotonically increased for putative on-cells and spinal neurons and decreased for putative off-cells. In the majority of simultaneous recordings of RVM and spinal neurons, the latency and discharge rate of the putativeon- or off-cell were highly correlated with the latency and discharge rateof the spinal neuron, and the stimulus/response slopes were similar. Theseresults show that putative on- and off-cells can encode the stimulus intensity in terms of response latency and discharge rate, and suggest that suchencoding closely reflects spinal neuronal encoding. This may be relevant for the transmission and modulation of pain information by RVM neurons. (C) 2001 International Association for the Study of Pain. Published by ElsevierScience B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:25:28