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Titolo:
The contribution of cortical and cancellous bone to dual-energy X-ray absorptiometry measurements in the female proximal femur
Autore:
Lundeen, GA; Knecht, SL; Vajda, EG; Bloebaum, RD; Hofmann, AA;
Indirizzi:
Dept Vet Affairs Med Ctr, Bone & Joint Res Lab, Salt Lake City Hlth Care Syst, Salt Lake City, UT 84148 USA Dept Vet Affairs Med Ctr Salt Lake City UT USA 84148 e City, UT 84148 USA
Titolo Testata:
OSTEOPOROSIS INTERNATIONAL
fascicolo: 3, volume: 12, anno: 2001,
pagine: 192 - 198
SICI:
0937-941X(2001)12:3<192:TCOCAC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINERAL DENSITY; FEMORAL-NECK; PHOTON-ABSORPTIOMETRY; HIP FRACTURE; LUMBAR SPINE; AGE; STRENGTH; ARTHROPLASTY; DENSITOMETRY; RADIOGRAPHY;
Keywords:
accuracy; cancellous bone; cortical bone; DXA; femur; human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Bloebaum, RD Dept Vet Affairs Med Ctr, Bone & Joint Res Lab, Salt Lake City Hlth Care Syst, 151F,500 Foothill Blvd, Salt Lake City, UT 84148 USA DeptVet Affairs Med Ctr 151F,500 Foothill Blvd Salt Lake City UT USA 84148
Citazione:
G.A. Lundeen et al., "The contribution of cortical and cancellous bone to dual-energy X-ray absorptiometry measurements in the female proximal femur", OSTEOPOR IN, 12(3), 2001, pp. 192-198

Abstract

Dual-energy X-ray absorptiometry (DXA) is the most common method for determining bone mineral density (BMD) in the proximal femur. However, there remain questions concerning the contribution of cortical and cancellous bone to this technology in the proximal femur. The purpose of this investigation was to identify structural and compositional characteristics of human bone in the proximal femur that significantly influence DXA BMD measurements. Twenty-four femora were obtained at autopsy from Caucasian females ranging inage from 17 to 92 years (mean +/- SD, 61 +/- 25 years). DXA scans were performed on each specimen with a Hologic QDR-2000 densitometer. Direct measurements were determined from proximal femoral sections for cancellous bone (volume fraction, ash fraction, cancellous cross-sectional area and percent cancellous cross-sectional area), cortical bone (thickness, ash fraction, porosity, cortical cross-sectional area and percent cortical cross-sectionalarea) and anteroposterior thickness. These parameters were compared with the associated DXA measurements by means of simple and multiple regressions. Cancellous volume fraction was the best predictor of Variability of DXA measurements for both the neck and trochanter, with an R-2 of 0.87 and 0.76, respectively (p <0.0001). There was only a minor influence of cortical factors such as thickness (neck and trochanter R-2 = 0.51 and 0.42, respectively, p <0.001) and trochanteric cross-sectional area (R-2 = 0.21, p <0.05). Although the accuracy for determining specific components of the proximal femur was low, the DXA BMD measurement was a strong predictor of cancellous bone factors, but not cortical bone factors that have been shown to change significantly with age.

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Documento generato il 28/09/20 alle ore 14:40:57