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Titolo:
The H-phosphonate approach to the synthesis of phosphopeptides on solid phase
Autore:
Kupihar, Z; Kele, Z; Toth, GK;
Indirizzi:
Univ Szeged, Dept Med Chem, H-6720 Szeged, Hungary Univ Szeged Szeged Hungary H-6720 Dept Med Chem, H-6720 Szeged, Hungary
Titolo Testata:
ORGANIC LETTERS
fascicolo: 7, volume: 3, anno: 2001,
pagine: 1033 - 1035
SICI:
1523-7060(20010405)3:7<1033:THATTS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTAINING PEPTIDES; PHOSPHORYLATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Toth, GK Univ Szeged, Dept Med Chem, Dom Ter 8, H-6720 Szeged, Hungary Univ Szeged Dom Ter 8 Szeged Hungary H-6720 6720 Szeged, Hungary
Citazione:
Z. Kupihar et al., "The H-phosphonate approach to the synthesis of phosphopeptides on solid phase", ORG LETT, 3(7), 2001, pp. 1033-1035

Abstract

Ammonium tert-butyl H-phosphonate was used for the phosphorylation of Tyr-and Ser-containing peptides synthesized by an Fmoc strategy. This reaction, leading to a monoprotected peptide phosphate, was found to be highly efficient and generally applicable. Moreover, the method employed avoids undesired side reactions during chain elongation (pyrophosphate formation and beta -elimination catalyzed by piperidine).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:59:00