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Titolo:
Single-step formation of structurally defined bicyclic peptides via SNAr cyclization
Autore:
Kohn, WD; Zhang, LS; Weigel, JA;
Indirizzi:
Eli Lilly & Co, Sphinx Labs, Cambridge, MA 02139 USA Eli Lilly & Co Cambridge MA USA 02139 phinx Labs, Cambridge, MA 02139 USA
Titolo Testata:
ORGANIC LETTERS
fascicolo: 7, volume: 3, anno: 2001,
pagine: 971 - 974
SICI:
1523-7060(20010405)3:7<971:SFOSDB>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLID SUPPORT SYNTHESIS; PROTEIN; DESIGN; ANALOGS; MACROCYCLES; METHODOLOGY; VENOMS; SITE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Kohn, WD Eli Lilly & Co, Sphinx Labs, 840 Mem Dr, Cambridge, MA 02139 USA Eli Lilly & Co 840 Mem Dr Cambridge MA USA 02139 ge, MA 02139 USA
Citazione:
W.D. Kohn et al., "Single-step formation of structurally defined bicyclic peptides via SNAr cyclization", ORG LETT, 3(7), 2001, pp. 971-974

Abstract

A solid-phase methodology for macrocyclization via an SNAr reaction has been developed for the unambiguous formation of bicyclic peptidic compounds in a single cyclization step. The cyclization strategy involves the reactionof a 3,5-dihydroxybenzoyl group with two nitrofluorobenzoyl moieties, The symmetry of the dihydroxy aromatic ring results in a single product, and the remaining nitro groups are subsequently reduced to anilines and acylated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 02:23:19