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Titolo:
An individual patient data meta-analysis of long supported adjuvant chemotherapy with oral carmofur in patients with curatively resected colorectal cancer
Autore:
Sakamoto, J; Kodaira, S; Hamada, C; Ito, K; Maehara, Y; Takagi, H; Sugimachi, K; Nakazato, H;
Indirizzi:
Aichi Prefectural Hosp, Dept Surg, Japanese Soc Strategies Canc Res & Therapy, Meta Anal Grp, Okazaki, Aichi 4440011, Japan Aichi Prefectural Hosp Okazaki Aichi Japan 4440011 , Aichi 4440011, Japan Aichi Prefectural Hosp, Lab Clin Oncol, Japanese Soc Strategies Canc Res &Therapy, Meta Anal Grp, Okazaki, Aichi 4440011, Japan Aichi Prefectural Hosp Okazaki Aichi Japan 4440011 , Aichi 4440011, Japan Teikyo Univ, Fac Med, Dept Surg 1, Tokyo 173, Japan Teikyo Univ Tokyo Japan 173 Univ, Fac Med, Dept Surg 1, Tokyo 173, Japan Univ Tokyo, Fac Med, Dept Pharmacoepidemiol, Tokyo 113, Japan Univ Tokyo Tokyo Japan 113 Med, Dept Pharmacoepidemiol, Tokyo 113, Japan Nagoya Univ, Sch Med, Dept Surg 2, Nagoya, Aichi 466, Japan Nagoya Univ Nagoya Aichi Japan 466 Dept Surg 2, Nagoya, Aichi 466, Japan Kyushu Univ, Fac Med, Dept Surg 2, Fukuoka 812, Japan Kyushu Univ Fukuoka Japan 812 , Fac Med, Dept Surg 2, Fukuoka 812, Japan Yokoyama Gastrointestinal Hosp, Dept Surg, Nagoya, Aichi, Japan Yokoyama Gastrointestinal Hosp Nagoya Aichi Japan , Nagoya, Aichi, Japan Univ Tokyo, Sch Hlth Sci & Nursing, Dept Epidemiol & Biostat, Tokyo, JapanUniv Tokyo Tokyo Japan Nursing, Dept Epidemiol & Biostat, Tokyo, Japan
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 3, volume: 8, anno: 2001,
pagine: 697 - 703
SICI:
1021-335X(200105/06)8:3<697:AIPDMO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HCFU STUDY-GROUP; FOLLOW-UP; CARCINOMA; VARIETY; TUMORS; URACIL;
Keywords:
colorectal cancer; meta-analysis; randomized trials; individual patient data; carmofur; curative resection; adjuvant chemotherapy; oral fluorinated pyrimidine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Sakamoto, J Aichi Prefectural Hosp, Dept Surg, Japanese Soc Strategies Canc Res & Therapy, Meta Anal Grp, 18 Kuriyado, Okazaki, Aichi 4440011, Japan Aichi Prefectural Hosp 18 Kuriyado Okazaki Aichi Japan 4440011
Citazione:
J. Sakamoto et al., "An individual patient data meta-analysis of long supported adjuvant chemotherapy with oral carmofur in patients with curatively resected colorectal cancer", ONCOL REP, 8(3), 2001, pp. 697-703

Abstract

To reappraise the benefits of the long supported chemotherapy with carmofur, a meta-analysis based on individual patient data from the three clinicaltrials was performed by pooling 614 patients from three trials, there is astatistically significant survival benefit (2p=0.032) and disease-free survival (DFS) benefit (2p=0.021) for carmofur; and a highly significant advantage for carmofur in DFS (2p=0.0004) and in survival (2p=0.004) in Dukes' Cpatients. This IPD meta-analysis strongly suggested an effect of oral carmofur in a long supported chemotherapy for curatively resected colorectal carcinoma.

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Documento generato il 25/11/20 alle ore 18:53:00