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Titolo:
Mitochondrial genotypes and radiation-induced micronucleus formation in human osteosarcoma cells in vitro
Autore:
Yoshida, K; Yamazaki, H; Ozeki, S; Inoue, T; Yoshioka, Y; Yoneda, M; Fujiwara, Y; Inoue, T;
Indirizzi:
Osaka Univ, Grad Sch Med, Div Multidisciplinary Radiotherapy, Suita, Osaka5650871, Japan Osaka Univ Suita Osaka Japan 5650871 otherapy, Suita, Osaka5650871, Japan Osaka Univ, Grad Sch Med, Dept Radiol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Radiol, Suita, Osaka 5650871, Japan Osaka Univ, Genome Informat Res Ctr, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Res Ctr, Suita, Osaka 5650871, Japan Fukui Med Univ, Dept Internal Med 2, Fukui, Japan Fukui Med Univ Fukui Japan Med Univ, Dept Internal Med 2, Fukui, Japan Kobe Univ, Sch Med, Dept Radiat Biophys & Genet, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 ys & Genet, Kobe, Hyogo 6500017, Japan
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 3, volume: 8, anno: 2001,
pagine: 615 - 619
SICI:
1021-335X(200105/06)8:3<615:MGARMF>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDATIVE-PHOSPHORYLATION; RADIOSENSITIVITY; COMPLEMENTATION; FIBROBLASTS; GENERATION; APOPTOSIS; STRESS; ASSAY; DEATH;
Keywords:
radiation; micronucleus; ATP; mitochondrial DNA; superoxide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Yoshida, K Osaka Univ, Grad Sch Med, Div Multidisciplinary Radiotherapy, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 50871, Japan
Citazione:
K. Yoshida et al., "Mitochondrial genotypes and radiation-induced micronucleus formation in human osteosarcoma cells in vitro", ONCOL REP, 8(3), 2001, pp. 615-619

Abstract

We investigated whether or not the mitochondrial genotypes affect radiation-induced micronucleus (MN) formation. For that purpose, the rho (+), KT1 and rho (0) human osteosarcoma cell lines were used, which carry the wild-type mitochondrial DNA (mtDNA), the tRNA(Lys) mutant mtDNA and no mtDNA, respectively. Despite no significant difference in the clonogenic radiosensitivity, the rho (+), KT1 and rho (0) cells exhibited high, intermediate and low radiosensitivities, respectively, to the MN induction in cytokinesis-blocked binucleated cells. Such differential MN inductions were correlated withhigh, intermediate and low levels of cellular ATP in the rho (+), KT1 and rho (0) cells, respectively, but not exactly with ROS production. AntimycinA that inhibits the respiratory complex III reduced the rate of radiation-induced MN induction in the rho (+) and KT1, but not rho (0) cells. Thus, the functional status of the mtDNA to produce ATP appears to play a significant role for radiation-induced MN.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 23:00:56