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Titolo:
Pharmacokinetics of intraoperative intrapleural cisplatin chemotherapy of various osmolarities in cases of esophageal cancer
Autore:
Katano, K; Tsujitani, S; Maeta, M; Fukuda, K; Oka, S; Hisamitsu, K; Ikeguchi, M; Kaibara, N;
Indirizzi:
Tottori Univ, Fac Med, Dept Surg 1, Yonago, Tottori 6838504, Japan TottoriUniv Yonago Tottori Japan 6838504 Yonago, Tottori 6838504, Japan
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 3, volume: 8, anno: 2001,
pagine: 605 - 609
SICI:
1021-335X(200105/06)8:3<605:POIICC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT PLEURAL MESOTHELIOMA; INTRAPERITONEAL CISPLATIN; PERITONEAL CARCINOMATOSIS; CLINICAL STATUS; TOXICITY; SURGERY; INVITRO;
Keywords:
intrapleural chemotherapy; fluid osmolarity; cisplatin; carcinomatosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Katano, K Tottori Univ, Fac Med, Dept Surg 1, 36-1 Nishi Cho, Yonago, Tottori 6838504, Japan Tottori Univ 36-1 Nishi Cho Yonago Tottori Japan 6838504, Japan
Citazione:
K. Katano et al., "Pharmacokinetics of intraoperative intrapleural cisplatin chemotherapy of various osmolarities in cases of esophageal cancer", ONCOL REP, 8(3), 2001, pp. 605-609

Abstract

Intraoperative intrapleural (i.pl.) cisplatin (CDDP) treatment during thoracotomy was performed for esophageal cancers. Three patients underwent isotonic (308 mOsm/1) CDDP treatment. Hypotonic CDDP treatments with a 154 mOsm/1 solution and a 62 mOsm/1 solution were administered to 4 and 9 patients,respectively. The maximum concentrations (C-max) of both total and filterable platinum in the plasma after injection of the hypotonic solution were significantly higher than those after injection of the isotonic solution. The area under the curve of concentration versus time (AUC) of the plasma of the 62 mOsm/1 solution was significantly higher than that of the 154 mOsm/1and isotonic solution. Although higher levels of the C-max may increase side-effects, the hypotonic condition of the i.pl. fluid and increased AUC inthe plasma may escalate the accumulation of platinum in i.pl. cancer cells. These results suggest that hypotonic i.pl. CDDP is tolerable and may be useful for treatment of the incipient phase of pleural carcinomatosis and for prophylaxis of postoperative recurrence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:40:30