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Titolo:
Altered HPA axis responsivity to metyrapone testing in methadone maintained former heroin addicts with ongoing cocaine addiction
Autore:
Schluger, JH; Borg, L; Ho, A; Kreek, MJ;
Indirizzi:
Rockefeller Univ, Lab Biol Addict Dis, New York, NY 10021 USA Rockefeller Univ New York NY USA 10021 Addict Dis, New York, NY 10021 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 24, anno: 2001,
pagine: 568 - 575
SICI:
0893-133X(200105)24:5<568:AHARTM>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; BETA-ENDORPHIN LEVELS; MAINTENANCE TREATMENT; OPIOID RECEPTORS; DEPENDENT MEN; DRUG-SEEKING; CORTISOL; NALOXONE; ACTH; BUPRENORPHINE;
Keywords:
metyrapone; cocaine; methadone; addiction; ACTH; HPA axis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Schluger, JH Rockefeller Univ, Lab Biol Addict Dis, 1230 York Ave, New York, NY 10021 USA Rockefeller Univ 1230 York Ave New York NY USA 10021 0021 USA
Citazione:
J.H. Schluger et al., "Altered HPA axis responsivity to metyrapone testing in methadone maintained former heroin addicts with ongoing cocaine addiction", NEUROPSYCH, 24(5), 2001, pp. 568-575

Abstract

Metyrapone testing, a provocation of hypothalamic-pituitary-adrenocortical(HPA) axis function, teas performed in 39 in-patient subjects: 10 stable methadone-maintained former heroin addicts without ongoing drug or alcohol abuse or dependence (MM), eight methadone-maintained former heroin addicts without ongoing drug or alcohol abuse or dependence other than ongoing cocaine dependence (C-MM), and 21 normal volunteers (NV). Plasma adrenocorticotrophic hormone (ACTH) levels were determined in samples drawn at 9A.M., justbefore administration of 2.25 g metyrapone orally and 4 and 8 hours afterward. Following metyrapone, C-MM had levels of ACTH that were significantly higher than both MM (p < .05) and NV (p < .01); whereas, MM and NV had levels that were comparable. Area under the plasma ACTH curves yielded similar results. This study documents hyper responsivity to removal of glucocorticoid negative feedback associated with cocaine addiction, even in the settingof methadone maintenance for heroin addiction, which here and previously has been shown to be associated with normalization of HPA axis function. (C)2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 23:00:09