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Titolo:
Striatal dopaminergic and serotonergic markers in human heroin users
Autore:
Kish, SJ; Kalasinsky, KS; Derkach, P; Schmunk, GA; Guttman, M; Ang, L; Adams, V; Furukawa, Y; Haycock, JW;
Indirizzi:
Ctr Addict & Mental Hlth, Human Neurochem Pathol, Toronto, ON M5T 1R8, Canada Ctr Addict & Mental Hlth Toronto ON Canada M5T 1R8 to, ON M5T 1R8, Canada Armed Forces Inst Pathol, Off Armed Forces Med Examiner, Div Forens Toxicol, Washington, DC 20306 USA Armed Forces Inst Pathol Washington DC USA 20306 Washington, DC 20306 USA Stanford Univ, Palo Alto, CA 94304 USA Stanford Univ Palo Alto CA USA 94304 anford Univ, Palo Alto, CA 94304 USA Sunnybrook Hosp, Dept Pathol Neuropathol, Toronto, ON, Canada Sunnybrook Hosp Toronto ON Canada athol Neuropathol, Toronto, ON, Canada Louisiana State Univ, Med Ctr, Dept Biochem & Mol Biol, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 , New Orleans, LA 70112 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 24, anno: 2001,
pagine: 561 - 567
SICI:
0893-133X(200105)24:5<561:SDASMI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
VESICULAR MONOAMINE TRANSPORTER; IDIOPATHIC PARKINSONS-DISEASE; VENTRAL TEGMENTAL AREA; CHRONIC MORPHINE; CHRONIC COCAINE; TYROSINE-HYDROXYLASE; ASCORBIC-ACID; RAT-BRAIN; SYSTEM; WITHDRAWAL;
Keywords:
heroin; opiate; dopamine; serotonin; dopamine transporter; vesicular monoamine transporter; extracellular signal-regulated kinase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Kish, SJ Ctr Addict & Mental Hlth, Human Neurochem Pathol, 250 Coll St, Toronto, ONM5T 1R8, Canada Ctr Addict & Mental Hlth 250 Coll St Toronto ON Canada M5T 1R8 da
Citazione:
S.J. Kish et al., "Striatal dopaminergic and serotonergic markers in human heroin users", NEUROPSYCH, 24(5), 2001, pp. 561-567

Abstract

To establish whether chronic opiate exposure might impair brain dopaminergic or serotonergic function in humans, we assessed biochemical indicts of monoaminergic neurotransmitter activity and integrity in post mortem striatum of nine chronic heroin users and 14 control subjects. Striatal levels of the vesicular monoamine transporter were normal, suggesting that the density of dopamine nerve terminals is not reduced in heroin users. III nucleus accunbens, levels of tyrosine hydroxylase protein (-25%) and those of the dopamine metabolite homovanillic acid (-33%) were reduced significantly together with a trend for decreased dopamine (-32%) concentration. These changescould reflect tither a compensatory downregulation of dopamine biosynthesis in response to prolonged dopaminergic stimulation caused by heroin, or reduced axoplasmic transport of tyrosine hydroxylase. Striatal levels of serotonin were either normal or elevated whereas concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid were decreased by 27-38%. Our data suggest that chronic heroin exposure might produce a modest reduction in dopaminergic and serotonergic activity that could affect motivational state and impulse control, respectively. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 11:04:06