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Titolo:
The variable number of tandem repeats polymorphism of the dopamine transporter gene is not associated with significant change in dopamine transporterphenotype in humans
Autore:
Martinez, D; Gelernter, J; Abi-Dargham, A; van Dyck, CH; Kegeles, L; Innis, RB; Laruelle, M;
Indirizzi:
New York State Psychiat Inst, Div Funct Brain Mapping, New York, NY 10032 USA New York State Psychiat Inst New York NY USA 10032 New York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Radiol, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 , Dept Psychiat, New Haven, CT 06510 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 24, anno: 2001,
pagine: 553 - 560
SICI:
0893-133X(200105)24:5<553:TVNOTR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIT HYPERACTIVITY DISORDER; I-123 BETA-CIT; SEROTONIN TRANSPORTERS; ALCOHOL DEPENDENCE; CIGARETTE SMOKERS; C-11 RACLOPRIDE; BRAIN; SCHIZOPHRENIA; AMPHETAMINE; TRANSMISSION;
Keywords:
single photon emission tomography; dopamine uptake transporter; dopamine type 2 receptor; striatum; genotype; human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Martinez, D New York State Psychiat Inst, Div Funct Brain Mapping, 1051 Riverside Dr,Box 31, New York, NY 10032 USA New York State Psychiat Inst 1051Riverside Dr,Box 31 New York NY USA 10032
Citazione:
D. Martinez et al., "The variable number of tandem repeats polymorphism of the dopamine transporter gene is not associated with significant change in dopamine transporterphenotype in humans", NEUROPSYCH, 24(5), 2001, pp. 553-560

Abstract

A 40 base polymorphism of a variable number of tandem repeats (VNTR) has been described in the 3 ' untranslated region of the gene (SLC6A3) coding for the dopamine transporter (DAT). Despite bring located in tire untranslated region of the gene, this polymorphism has been associated with clinical phenotypes associated with dysregulation of dopamine transmission, such as attention deficit hyperactivity disorder and cocaine-induced paranoia. To examine the neurochemical phenotype associated with this polymorphism, we compared amphetamine-induced dopamine release (measured ns displacement of tile radiotracer [I-123]IBZMI and DAT expression (measured with [I-123]beta -CIT) in the striatum with Single Photon Computerized Emission Tomography (SPECT). Our sample included 59 subjects, 31 healthy controls and 29 patients with schizophrenia. No significant association was found between VNTR polymorphism and amphetamine-induced dopamine release or DAT density in the total sample, nor when each diagnostic group tons considered separately. Thus, we dill trot replicate the findings of two previous studies, which had suggested that the 9 repeat allele was associated with either an increased or decreased DAT expression, albeit in different patient populations. (C) American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:49:48