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Titolo:
Abnormal kainate receptor expression in prefrontal cortex in schizophrenia
Autore:
Meador-Woodruff, JH; Davis, KL; Haroutunian, V;
Indirizzi:
Univ Michigan, Dept Psychiat, Mental Hlth Res Inst, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 th Res Inst, Ann Arbor, MI 48109 USA CUNY Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA CUNY Mt SinaiSch Med New York NY USA 10029 chiat, New York, NY 10029 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 24, anno: 2001,
pagine: 545 - 552
SICI:
0893-133X(200105)24:5<545:AKREIP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEGATIVE SYMPTOMS; MESSENGER-RNAS; GLUTAMATE RECEPTORS; CHANNEL PROPERTIES; D-CYCLOSERINE; BRAIN-TISSUE; STRIATUM; BINDING; NEUROLEPTICS; POSTMORTEM;
Keywords:
glutamate; prefrontal cortex; striatum; in situ hybridisation; receptor autoradiography; ionotropic glutamate receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Meador-Woodruff, JH Univ Michigan, Dept Psychiat, Mental Hlth Res Inst, 205 Zina Pitcher Pl, Ann Arbor, MI 48109 USA Univ Michigan 205 Zina Pitcher Pl Ann Arbor MI USA 48109
Citazione:
J.H. Meador-Woodruff et al., "Abnormal kainate receptor expression in prefrontal cortex in schizophrenia", NEUROPSYCH, 24(5), 2001, pp. 545-552

Abstract

Abnormalities of molecules associated with the glutamate synapse have beenimplicated in the pathophysiology of schizophrenia. Of the many glutamate receptors, those most commonly suggested to be involved in schizophrenia are the ionotropic subtypes, the NMDA, AMPA, and kainate receptors. Both the NMDA and AMPA subtypes have berl? extensively studied in postmortem brains of individuals with schizophrenia, but relatively little is known about theexpression of the kainate subtype of glutamate receptor. In this study, wehave determined cortical and striatal kainate receptor expression in brains from persons with schizophrenia and a comparison group, using both in situ hybridization and receptor autoradiography. At the level of subunit mRNA expression, a shift in subunit stoichiometry teas evident in multiple regions of the prefrontal cortex, with increased expression of gluR7 mRNA and decreased expression of KA2 mRNA. Decreased kainate receptor binding was alsoobserved in the subjects with schizophrenia, but was restricted to infragranular laminae of tire prefrontal cortex. No differences in kainate receptor binding or subunit mRNA levels were found ill striatum or occipital cortex, suggesting that these findings may be restricted to association cortex. These data add to the gr growing literature implicating ionotropic glutamate receptor disturbances in schizophrenia, and indicate that in addition to AMPA and NMDA receptors, the kainate receptors are also abnormally expressed in this illness. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 21/01/20 alle ore 01:05:15