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Titolo:
Effects of antidepressant drugs on the behavioral and physiological responses to lipopolysaccharide (LPS) in rodents
Autore:
Yirmiya, R; Pollak, Y; Barak, O; Avitsur, R; Ovadia, H; Bette, M; Weihe, E; Weidenfeld, J;
Indirizzi:
Hebrew Univ Jerusalem, Dept Psychol, IL-91905 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91905 -91905 Jerusalem, Israel Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Neurol, IL-91010 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91010 -91010 Jerusalem, Israel Univ Marburg, Dept Mol Neuroimmunol, Inst Anat & Cell Biol, Marburg, Germany Univ Marburg Marburg Germany l, Inst Anat & Cell Biol, Marburg, Germany
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 24, anno: 2001,
pagine: 531 - 544
SICI:
0893-133X(200105)24:5<531:EOADOT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; PITUITARY-ADRENAL AXIS; LONG-TERM FLUOXETINE; MAJOR DEPRESSION; RAT-BRAIN; NEUROENDOCRINE RESPONSES; THERAPEUTIC IMPLICATIONS; TYROSINE-HYDROXYLASE; CYTOKINE PRODUCTION; INTERFERON-GAMMA;
Keywords:
fluoxetine (Prozac); imipramine; lipopolysaccharide (LPS); tumor necrosis factor-alpha (TNF alpha); iInterleukin-1 beta (IL-1 beta); corticotrophin-releasing hormone (CRH); corticosterone; fever; depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Yirmiya, R Hebrew Univ Jerusalem, Dept Psychol, Mt Scopus, IL-91905 Jerusalem, Israel Hebrew Univ Jerusalem Mt Scopus Jerusalem Israel IL-91905 rael
Citazione:
R. Yirmiya et al., "Effects of antidepressant drugs on the behavioral and physiological responses to lipopolysaccharide (LPS) in rodents", NEUROPSYCH, 24(5), 2001, pp. 531-544

Abstract

Antidepressants produce various immunomodulatory effects, as well as an attenuation of the behavioral responses to immune challenges, such as lipopolysaccharide (LPS). To explore further the effects of antidepressants on neuroimmune interactions, rats were treated daily with either fluoxetine (Prozac) or saline for 5 weeks, and various behavioral, neuroendocrine, and immune functions were measured following administration of either LPS or saline. Chronic fluoxetine treatment significantly attenuated tire anorexia and body weight loss, ns well as the depletion oi CXH-41 from tile median eminence and the elevation in serum corticosterone levels induced by LPS. Chronictreatment with imipramine also attenuated LPS-induced adrenocortical activation. In vats and in mice, which normally display a biphasic body temperature response to LPS (initial hypothermia followed by hyperthermia), chronictreatment with fluoxetine completely abolished tile hypothermic response and facilitated and strengthened the hyperthermic response. The effects of antidepressants on the responsiveness to LPS are probably not mediated by their effects on peripheral proinflammatory cytokine production, because LPS-induced expression of TNF alpha and IL-1 beta mRNA in the spleen (assessed by semiquantitative in situ hybridization) was not altered following chronic treatment with either fluoxetine or imipramine. The effects of antidepressants on the acute phase response may have important clinical implications for the psychiatric and neuroendocrine disturbances that are commonly associated with various medical conditions. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:02:06