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Titolo:
The serotonin reuptake inhibitor fluoxetine reduces sex steroid-related aggression in female rats: An animal model of premenstrual irritability?
Autore:
Ho, HP; Olsson, M; Westberg, L; Melke, J; Eriksson, E;
Indirizzi:
Univ Gothenburg, Dept Pharmacol, SE-40530 Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden SE-40530 , SE-40530 Gothenburg, Sweden
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 24, anno: 2001,
pagine: 502 - 510
SICI:
0893-133X(200105)24:5<502:TSRIFR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACEBO-CONTROLLED TRIAL; FORCED SWIMMING TEST; REPLACEMENT THERAPY; MENSTRUAL-CYCLE; ESTROUS-CYCLE; BEHAVIOR; DYSPHORIA; WOMEN; PSEUDOPREGNANCY; ANTIDEPRESSANTS;
Keywords:
aggression; irritability; estrus cycle; resident intruder paradigm; serotonin; serotonin reuptake inhibitor; fluoxetine; premenstrual dysphoria; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Ho, HP Univ Gothenburg, Dept Pharmacol, POB 431, SE-40530 Gothenburg, Sweden Univ Gothenburg POB 431 Gothenburg Sweden SE-40530 henburg, Sweden
Citazione:
H.P. Ho et al., "The serotonin reuptake inhibitor fluoxetine reduces sex steroid-related aggression in female rats: An animal model of premenstrual irritability?", NEUROPSYCH, 24(5), 2001, pp. 502-510

Abstract

Tile aggressive behavior displayed by some (but not ail) female Wistar rats when an unfamiliar rat is bring introduced into their home cage (the resident intruder paradigm) was found to be higher in non-receptive phases (metestrus, diestrus) than in the receptive phases (proestrus, estrus) of the estrus cycle, and effectively reduced by ovariectomy. When removal of the ovaries was followed by administration of estradiol and progesterone, ill a regimen mimicking the normal cyclical release of these hormones, aggressive behavior was elicited, two days after estrus, in animals that had displayedaggressive behavior before ovarietomy, but riot in those that had nor. Short-term administration of a serotonin reuptake inhibitor (fluoxetine hydrochloride; 10 mg/kg, i.p.; 4-5 days) reduced both the aggressive behavior displayed during the diestrus phase by normally cycling rats, and the aggressive behavior elicited by administration of estradiol plus progesterone afterovariectomy. It is suggested that the aggressive behavior displayed by thefemale Wistar rat in the resident intruder paradigm may serve as all animal model of premenstrual dysphoria.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:41:35