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Titolo:
The neurobiology and genetics of suicide and attempted suicide: A focus onthe serotonergic system
Autore:
Mann, JJ; Brent, DA; Arango, V;
Indirizzi:
New York State Psychiat Inst, Dept Neurosci, New York, NY 10032 USA New York State Psychiat Inst New York NY USA 10032 New York, NY 10032 USA Columbia Univ, Dept Psychiat, New York, NY 10032 USA Columbia Univ New York NY USA 10032 Dept Psychiat, New York, NY 10032 USA Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 sychiat, Pittsburgh, PA 15260 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 24, anno: 2001,
pagine: 467 - 477
SICI:
0893-133X(200105)24:5<467:TNAGOS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID MONOAMINE; TRYPTOPHAN-HYDROXYLASE GENE; H-3 PAROXETINE BINDING; TRITIATED IMIPRAMINE BINDING; BIOGENIC AMINE METABOLITES; 5-HT UPTAKE SITES; DEPRESSED-PATIENTS; TRANSPORTER GENE; MAJOR DEPRESSION; RECEPTOR GENE;
Keywords:
suicide; suicide attempt; candidate genes; serotonin; neuro-receptors;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
140
Recensione:
Indirizzi per estratti:
Indirizzo: Mann, JJ 1051 Riverside Dr,Box 42, New York, NY 10032 USA 1051 Riverside Dr,Box 42 New York NY USA 10032 ork, NY 10032 USA
Citazione:
J.J. Mann et al., "The neurobiology and genetics of suicide and attempted suicide: A focus onthe serotonergic system", NEUROPSYCH, 24(5), 2001, pp. 467-477

Abstract

Numerous abnormalities have been found in file serotonergic system in suicide attempters and completers. There is considerable evidence that the serotonergic system is partly under genetic control and that as yet unknown genetic factors mediate the risk for suicidal behavior independently of the genetic factors responsible for tile heritability of major psychiatric conditions associated with suicide. An argument is made that there is a relationship of genetic variants to intermediate phenotypes, such as impulsivity, psychomotor change, pathological aggression and biological abnormalities including specific gene products. A variety of biological indices have been generated by new approaches using postmortem tissue and in vivo imaging that a,ill pr ovine a rich substrate for further genetic studies. [Neuropsychopharmacology 24:467-477,2001] (C) 2001 American College of Neuropsychopharamacology. Published by Elsevier Science Inc..

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:35:27