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Titolo:
Dopaminergic lateralisation in the forebrain: Relations to behavioural asymmetries and anxiety in male Wistar rats
Autore:
Thiel, CM; Schwarting, RKW;
Indirizzi:
Univ Dusseldorf, Inst Physiol Psychol 1, D-4000 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-4000 1, D-4000 Dusseldorf, Germany
Titolo Testata:
NEUROPSYCHOBIOLOGY
fascicolo: 3, volume: 43, anno: 2001,
pagine: 192 - 199
SICI:
0302-282X(2001)43:3<192:DLITFR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED PLUS-MAZE; MEDIAL PREFRONTAL CORTEX; STRIATAL DOPAMINE; NUCLEUS-ACCUMBENS; LATERALIZED CHANGES; INDUCED ROTATION; IN-VIVO; BRAIN; DEPRESSION; DEPLETION;
Keywords:
anxiety; asymmetries; dopamine; lateralisation; scopolamine; open field;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Schwarting, RKW Univ Marburg, Gutenbergstr 18, D-35032 Marburg, Germany Univ Marburg Gutenbergstr 18 Marburg Germany D-35032 many
Citazione:
C.M. Thiel e R.K.W. Schwarting, "Dopaminergic lateralisation in the forebrain: Relations to behavioural asymmetries and anxiety in male Wistar rats", NEUROPSYCHB, 43(3), 2001, pp. 192-199

Abstract

Neurochemical lateralisation has been demonstrated in dopaminergic systemsin the rat brain, and it has been suggested that such lateralisation mightcontribute to asymmetric and emotional behaviour. Here, we investigated dopaminergic brain lateralisation in relation to spontaneous and drug-inducedbehavioural asymmetries, and to emotional behaviour in a sample of 24 maleWistar rats. Asymmetric behaviour was measured in the open field in the undrugged state and after a systemic challenge with the muscarinic receptor antagonist scopolamine (0.5 mg/kg). Emotional behaviour was measured in the elevated plus-maze. Dopaminergic lateralisation was assessed by means of a post-mortem analysis of tissue dopamine (DA) and dihydroxyphenyl acetic acid (DOPAC) content. We found higher DOPAC/DA ratios in the neostriatum, ventral striatum, frontal cortex and amygdala of the right hemisphere. In the open field, the complete sample of rats did not show a left/right asymmetry in spontaneous behaviour, whereas systemic scopolamine induced a left-sidedpreference in thigmotactic scanning. A correlational analysis yielded individual relationships between behaviour and postmortem neurochemistry, sincelateralisation of DOPAC/ DA ratios in favour of the right ventral striatumwas related to right-side thigmotaxis. Furthermore, a right dopaminergic lateralisation in the frontal cortex was associated with lower anxiety. The study indicates that asymmetries in ventral striatal dopamine might contribute to side preferences in thigmotactic scanning while frontal dopaminergiclateralisation might influence emotional processing. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 10:08:24