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Titolo:
Posttraumatic stress disorder: Diagnosis and epidemiology, comorbidity andsocial consequences, biology and treatment
Autore:
Brunello, N; Davidson, JRT; Deahl, M; Kessler, RC; Mendlewicz, J; Racagni, G; Shalev, AY; Zohar, J;
Indirizzi:
Univ Milan, Inst Pharmacol Sci, Ctr Neuropharmacol, I-20133 Milan, Italy Univ Milan Milan Italy I-20133 Ctr Neuropharmacol, I-20133 Milan, Italy Univ Modena & Reggio Emilia, Dept Pharmaceut Sci, Modena, Italy Univ Modena & Reggio Emilia Modena Italy Pharmaceut Sci, Modena, Italy Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC USA Duke Univ Durham NC USA d Ctr, Dept Psychiat & Behav Sci, Durham, NC USA St Bartholomews & Royal London Sch Med & Dent, London, England St Bartholomews & Royal London Sch Med & Dent London England n, England Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA HarvardUniv Boston MA USA 02115 t Hlth Care Policy, Boston, MA 02115 USA Univ Brussels, Erasme Hosp, Dept Psychiat, Brussels, Belgium Univ Brussels Brussels Belgium e Hosp, Dept Psychiat, Brussels, Belgium IRCCS, Ctr San Giovanni di Dio Fatebenefratelli, Brescia, Italy IRCCS Brescia Italy an Giovanni di Dio Fatebenefratelli, Brescia, Italy Hadassah Univ Hosp, Dept Psychiat, Ctr Traumat Stress, IL-91120 Jerusalem,Israel Hadassah Univ Hosp Jerusalem Israel IL-91120 , IL-91120 Jerusalem,Israel Chaim Sheba Med Ctr, Sackler Sch Med, IL-52621 Tel Hashomer, Israel Chaim Sheba Med Ctr Tel Hashomer Israel IL-52621 21 Tel Hashomer, Israel
Titolo Testata:
NEUROPSYCHOBIOLOGY
fascicolo: 3, volume: 43, anno: 2001,
pagine: 150 - 162
SICI:
0302-282X(2001)43:3<150:PSDDAE>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; EYE-MOVEMENT DESENSITIZATION; VIETNAM COMBAT VETERANS; PSYCHIATRIC-DISORDERS; HIPPOCAMPAL VOLUME; TRAUMATIC STRESS; OPEN TRIAL; SEXUAL ABUSE; PRIMARY-CARE; IMPACT;
Keywords:
posttraumatic stress disorder; treatment; antidepressants; pharmacoeconomics; tricyclic antidepressants; selective serotonin reuptake inhibitors;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
107
Recensione:
Indirizzi per estratti:
Indirizzo: Brunello, N Univ Milan, Inst Pharmacol Sci, Ctr Neuropharmacol, Via Balzaretti 9, I-20133 Milan, Italy Univ Milan Via Balzaretti 9 Milan Italy I-20133 Milan, Italy
Citazione:
N. Brunello et al., "Posttraumatic stress disorder: Diagnosis and epidemiology, comorbidity andsocial consequences, biology and treatment", NEUROPSYCHB, 43(3), 2001, pp. 150-162

Abstract

Epidemiological studies clearly indicate that posttraumatic stress disorder (PTSD) is becoming a major health concern worldwide even if still poorly recognized and not well treated. PTSD commonly co-occurs with other psychiatric disorders, and several symptoms overlap with major depressive disorders, anxiety disorders and substance abuse; this may contribute to diagnosticconfusion and underdiagnosis. This anxiety disorder provokes significant occupational, psychiatric, medical and psychosocial disability, and its consequences are enormously costly, not only to the survivors and their families, but also to the health care system and society. Work impairment associated with PTSD is very similar to the amount of work impairment associated with major depression. The pathophysiology of PTSD is multifactorial and involves dysregulation of the serotonergic as well as the noradrenergic system. A rational therapeutic approach should normalize the specific psychobiological alterations associated with PTSD. This can be achieved through the useof antidepressant drugs, mainly of those that potentiate serotonergic mechanisms. Recent double-blind placebo-controlled studies report the efficacy of selective serotonin reuptake inhibitors. Several cognitive-behavioral and psychosocial treatments have also been reported to be efficacious and could be considered when treating PTSD patients. Copyright (C) 2001 S. Karger AG,Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:30:53