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Titolo:
Antidepressive response to sleep deprivation in unipolar depression is notassociated with dopamine D3 receptor genotype
Autore:
Schumann, N; Benedetti, F; Voderhholzer, U; Kammerer, N; Hemmeter, U; Travers, HW; Fiebich, B; Holsboer-Trachsler, E; Berger, M; Seifritz, E; Ebert, D;
Indirizzi:
Univ Freiburg, Dept Psychiat, D-7800 Freiburg, Germany Univ Freiburg Freiburg Germany D-7800 Psychiat, D-7800 Freiburg, Germany Univ Milan, Sch Med, Hosp San Raffaele, Sci Inst,Dept Neuropsychiat Sci, Milan, Italy Univ Milan Milan Italy e, Sci Inst,Dept Neuropsychiat Sci, Milan, Italy Univ Basel, Dept Psychiat, CH-4003 Basel, Switzerland Univ Basel Basel Switzerland CH-4003 sychiat, CH-4003 Basel, Switzerland Univ Frankfurt, Dept Psychiat, D-6000 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-6000 chiat, D-6000 Frankfurt, Germany
Titolo Testata:
NEUROPSYCHOBIOLOGY
fascicolo: 3, volume: 43, anno: 2001,
pagine: 127 - 130
SICI:
0302-282X(2001)43:3<127:ARTSDI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE; POLYMORPHISM; DISORDERS; CORTISOL;
Keywords:
sleep deprivation; dopamin D3 receptor; genetic polymorphism; HPA system; cortisol; unipolar depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Schumann, N Cent Inst Mental Hlth, J5, D-68159 Mannheim, Germany Cent InstMental Hlth J5 Mannheim Germany D-68159 im, Germany
Citazione:
N. Schumann et al., "Antidepressive response to sleep deprivation in unipolar depression is notassociated with dopamine D3 receptor genotype", NEUROPSYCHB, 43(3), 2001, pp. 127-130

Abstract

The psychostimulant theory of antidepressive sleep deprivation (SD) proposes a contribution of dopamine D3 receptors (DRD3) in the limbic system to the antidepressant effects of SD. Neuroendocrinological studies suggest a positive correlation of clinical response to SD and cortisol secretion, We hypothesized that the clinical response to SD and amount of cortisol secretion upon SD is associated with the 1-1 genotype of the Ball polymorphism of DRD3 on exon 1, In this study, aiming at evaluating the feasibility of screening large patient samples, 52 inpatients (19 males/33 females) with unipolar depression and a score of 18 or more on the 21-item Hamilton Depression Rating Scale were treated with 1 night of total SD. We found th at 31% of our patients responded to SD, There was no association between response to SD and the genotype of the DRD3 Ball polymorphism (p < 0.879). There was also no association between increase in cortisol secretion after SD and DRD3 genotypes (p < 1.000) in a subgroup of patients. Statistical power analysis ruled out a major effect of the DRD3 Ball polymorphism on clinical responseto SD. These results suggest that the DRD3 Ball polymorphism is not a promising lead to be followed up in larger patient samples. Copyright (C) 2001 S. Karger AG. Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 10:37:55